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Promising targets of cell death signaling of NR2B receptor subunit in stroke pathogenesis

Overview of attention for article published in Regenerative Medicine Research, January 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)

Mentioned by

twitter
5 tweeters

Citations

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13 Dimensions

Readers on

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13 Mendeley
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Title
Promising targets of cell death signaling of NR2B receptor subunit in stroke pathogenesis
Published in
Regenerative Medicine Research, January 2014
DOI 10.1186/2050-490x-2-8
Pubmed ID
Authors

Shu, Lei Pei, Youming Lu

Abstract

Stroke is an acute cerebrovascular disease caused by acute brain artery bursting or cerebral embolism that leads to neuronal death and severe dysfunction of synaptic transmission. Neuronal damage after stroke remains a major cause of morbidity and mortality worldwide and affects 795 000 of lives every year in United States. However, effective treatments remain lacking, which makes the identification of new therapeutic targets a matter of great importance. N-methyl-D-aspartate glutamate (NMDA) receptor is important both in the normal synaptic transmission and in the neuronal death after stroke. Accumulated evidences show NMDA receptor downstream effectors, such as PSD-95, DAPK1, and ERK, had been revealed to be linked with neuronal damage. Based on our recent studies, we review the promising targets of the NMDA receptor downstream signaling involved in stroke treatment. This review will provide the concept of NR2B downstream signaling in neuronal death after stroke and provide evidences for developing better NMDAR-based therapeutics by targeting downstream proteins.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 8%
Unknown 12 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 31%
Student > Postgraduate 3 23%
Student > Bachelor 2 15%
Student > Master 1 8%
Student > Doctoral Student 1 8%
Other 2 15%
Readers by discipline Count As %
Neuroscience 6 46%
Agricultural and Biological Sciences 3 23%
Medicine and Dentistry 2 15%
Biochemistry, Genetics and Molecular Biology 1 8%
Unknown 1 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2018.
All research outputs
#7,057,718
of 12,504,607 outputs
Outputs from Regenerative Medicine Research
#8
of 22 outputs
Outputs of similar age
#80,001
of 193,492 outputs
Outputs of similar age from Regenerative Medicine Research
#1
of 1 outputs
Altmetric has tracked 12,504,607 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22 research outputs from this source. They receive a mean Attention Score of 2.0. This one scored the same or higher as 14 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,492 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them