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Analysis of β-N-methylamino-L-alanine (BMAA) in spirulina-containing supplements by liquid chromatography-tandem mass spectrometry

Overview of attention for article published in Aquatic Biosystems, August 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

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9 X users
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1 Facebook page
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2 Redditors
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1 YouTube creator

Citations

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29 Dimensions

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69 Mendeley
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Title
Analysis of β-N-methylamino-L-alanine (BMAA) in spirulina-containing supplements by liquid chromatography-tandem mass spectrometry
Published in
Aquatic Biosystems, August 2014
DOI 10.1186/2046-9063-10-5
Pubmed ID
Authors

Pearse McCarron, Alan C Logan, Sabrina D Giddings, Michael A Quilliam

Abstract

Over the last decade the amino acid beta-N-methylamino-L-alanine (BMAA) has come under intense scrutiny. International laboratory and epidemiological research continues to support the hypothesis that environmental exposure to BMAA (e.g., through dietary practices, water supply) can promote the risk of various neurodegenerative diseases. A wide variety of cyanobacteria spp. have previously been reported to produce BMAA, with production levels dependent upon species, strain and environmental conditions. Since spirulina (Arthrospira spp.) is a member of the cyanobacteria phylum frequently consumed via dietary supplements, the presence of BMAA in such products may have public health implications. In the current work, we have analyzed ten spirulina-containing samples for the presence of BMAA; six pure spirulina samples from two separate raw materials suppliers, and four commercially-available multi-ingredient products containing 1.45 g of spirulina per 8.5 g serving. Because of controversy surrounding the measurement of BMAA, we have used two complementary liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods: one based on reversed phase LC (RPLC) with derivatization and the other based on hydrophilic interaction LC (HILIC). Potential matrix effects were corrected for by internal standardization using a stable isotope labeled BMAA standard. BMAA was not detected at low limits of detection (80 ng/g dry weight) in any of these product samples. Although these results are reassuring, BMAA analyses should be conducted on a wider sample selection and, perhaps, as part of ongoing spirulina production quality control testing and specifications.

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X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 1%
Unknown 68 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 19%
Student > Bachelor 10 14%
Student > Ph. D. Student 8 12%
Researcher 7 10%
Student > Doctoral Student 6 9%
Other 18 26%
Unknown 7 10%
Readers by discipline Count As %
Chemistry 18 26%
Agricultural and Biological Sciences 15 22%
Biochemistry, Genetics and Molecular Biology 7 10%
Medicine and Dentistry 4 6%
Environmental Science 3 4%
Other 12 17%
Unknown 10 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2023.
All research outputs
#5,188,035
of 24,877,044 outputs
Outputs from Aquatic Biosystems
#13
of 47 outputs
Outputs of similar age
#48,071
of 236,129 outputs
Outputs of similar age from Aquatic Biosystems
#1
of 5 outputs
Altmetric has tracked 24,877,044 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 47 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one scored the same or higher as 34 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,129 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them