Title |
Involvement of Seladin-1 in goniothalamin-induced apoptosis in urinary bladder cancer cells
|
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Published in |
BMC Complementary Medicine and Therapies, August 2014
|
DOI | 10.1186/1472-6882-14-295 |
Pubmed ID | |
Authors |
Heng Kai Yen, Afifah-Radiah Fauzi, Laily Bin Din, Valerie J McKelvey-Martin, Chan Kok Meng, Salmaan Hussain Inayat-Hussain, Nor Fadilah Rajab |
Abstract |
Selective Alzheimer Disease Indicator-1 (or Seladin-1) is a multifunctional protein first discovered by downregulation of its expression in Alzheimer's disease. Interestingly, the expression of this protein is upregulated in several cancers, including primary bladder cancer. However, its role in cancer formation has yet to be discovered. Goniothalamin is a natural product that has been demonstrated to induce apoptosis in various cancer cell lines. In this study, we have elucidated the role of Seladin-1 in goniothalamin-induced cytotoxicity towards human urinary bladder cancer cell line RT4. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
United Kingdom | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 25% |
Lecturer | 3 | 13% |
Student > Master | 3 | 13% |
Student > Bachelor | 2 | 8% |
Other | 2 | 8% |
Other | 4 | 17% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 29% |
Agricultural and Biological Sciences | 5 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 17% |
Psychology | 2 | 8% |
Medicine and Dentistry | 1 | 4% |
Other | 1 | 4% |
Unknown | 4 | 17% |