Title |
The immune mechanism of Mycoplasma hyopneumoniae 168 vaccine strain through dendritic cells
|
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Published in |
BMC Veterinary Research, September 2017
|
DOI | 10.1186/s12917-017-1194-1 |
Pubmed ID | |
Authors |
Yumeng Shen, Weiwei Hu, Yanna Wei, Zhixin Feng, Qian Yang |
Abstract |
Mycoplasma hyopneumoniae (Mhp) causes porcine enzootic pneumonia, a disease that cause major economic losses in the pig industry. Dendritic cells (DCs), the most effective antigen-presenting cells, are widely distributed beneath respiratory epithelium, DCs uptake and present antigens to T cells, to initiate protective immune responses in different infections. In this study, we investigated the role of porcine DCs in vaccine Mhp-168 exposure. The antigen presenting ability of DCs were improved by vaccine Mhp-168 exposure. DCs could activate T-cell proliferation by up-regulating the antigen presenting molecule MHCII expression and co-stimulatory molecule CD80/86. However, the up-regulation of IL-10 and accompany with down-regulation of IFN-γ gene level may account for the limitation of attenuated Mhp-168 strain use as vaccine alone. These findings are benefit for exploring the protection mechanisms and the possible limitations of this attenuated Mhp-168 vaccine. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 22% |
Researcher | 5 | 22% |
Student > Ph. D. Student | 5 | 22% |
Student > Bachelor | 2 | 9% |
Student > Postgraduate | 2 | 9% |
Other | 2 | 9% |
Unknown | 2 | 9% |
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Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Other | 2 | 9% |
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