Title |
Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies
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Published in |
Cardiovascular Diabetology, August 2014
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DOI | 10.1186/s12933-014-0123-x |
Pubmed ID | |
Authors |
Shang-Hung Chang, Lung-Sheng Wu, Meng-Jiun Chiou, Jia-Rou Liu, Kuang-Hui Yu, Chang-Fu Kuo, Ming-Shien Wen, Wei-Jan Chen, Yung-Hsin Yeh, Lai-Chu See |
Abstract |
Atrial fibrillation (AF), an inflammatory process involving arrhythmia, is associated with severe morbidity and mortality and commonly seen in patients with diabetes mellitus (DM). The effect of metformin, the most commonly used medication for patients with DM, on AF has not been investigated. The primary aim of this study was to examine whether metformin prevented the occurrence of AF in type 2 DM patients by analyzing a nationwide, population-based dynamic cohort. Additionally, we investigated the effect of metformin on tachycardia-induced myolysis and oxidative stress in atrial cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 60% |
Spain | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 130 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 19 | 15% |
Student > Bachelor | 15 | 12% |
Student > Ph. D. Student | 14 | 11% |
Other | 12 | 9% |
Student > Master | 10 | 8% |
Other | 16 | 12% |
Unknown | 44 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 50 | 38% |
Biochemistry, Genetics and Molecular Biology | 6 | 5% |
Agricultural and Biological Sciences | 6 | 5% |
Nursing and Health Professions | 3 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 9 | 7% |
Unknown | 53 | 41% |