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Strategies to overcome trastuzumab resistance in HER2-overexpressing breast cancers: focus on new data from clinical trials

Overview of attention for article published in BMC Medicine, August 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

blogs
1 blog
twitter
5 X users
patent
2 patents

Citations

dimensions_citation
66 Dimensions

Readers on

mendeley
139 Mendeley
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Title
Strategies to overcome trastuzumab resistance in HER2-overexpressing breast cancers: focus on new data from clinical trials
Published in
BMC Medicine, August 2014
DOI 10.1186/s12916-014-0132-3
Pubmed ID
Authors

Pernelle Lavaud, Fabrice Andre

Abstract

Breast cancers over-express the human epidermal growth factor receptor 2 (HER2) in about 15% of patients. This transmembrane tyrosine kinase receptor activates downstream signaling pathways and leads to proliferation of cancer cells. Trastuzumab, an anti-HER2 monoclonal antibody, improves outcome in women with early and metastatic breast cancer. Resistance to trastuzumab involves the phosphoinositide 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway, truncation of the Her2 receptor or lack of immune response. The last decade has seen major advances in strategies to overcome resistance to trastuzumab. This includes the development of antibody-drug conjugates, dual HER2 inhibition strategies, inhibition of PI3K/mTOR pathway and development of modulators of immune checkpoints.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 1%
Ecuador 1 <1%
United Kingdom 1 <1%
Belgium 1 <1%
Denmark 1 <1%
Unknown 133 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 19%
Researcher 22 16%
Student > Master 22 16%
Student > Bachelor 22 16%
Other 8 6%
Other 16 12%
Unknown 23 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 33 24%
Agricultural and Biological Sciences 30 22%
Medicine and Dentistry 26 19%
Pharmacology, Toxicology and Pharmaceutical Science 6 4%
Immunology and Microbiology 4 3%
Other 12 9%
Unknown 28 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2021.
All research outputs
#1,901,758
of 22,760,687 outputs
Outputs from BMC Medicine
#1,276
of 3,413 outputs
Outputs of similar age
#20,631
of 231,106 outputs
Outputs of similar age from BMC Medicine
#22
of 60 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,413 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.5. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,106 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.