Title |
Is Sjögren's syndrome a retroviral disease?
|
---|---|
Published in |
Arthritis Research & Therapy, April 2011
|
DOI | 10.1186/ar3262 |
Pubmed ID | |
Authors |
Nikolaos V Sipsas, Maria N Gamaletsou, Haralampos M Moutsopoulos |
Abstract |
Circumstantial evidence suggests that retroviruses play a role in the pathogenesis of Sjögren's syndrome. Such evidence, derived from studies of patients with Sjögren's syndrome, includes the following: the presence of serum antibodies cross-reactive with retroviral Gag proteins; the occurrence of reverse transcriptase activity in salivary glands; the detection of retroviral antigens, retrovirus-like particles, or novel retroviral sequences in salivary glands; the occurrence of Sjögren's syndrome-like illnesses in patients having confirmed systematic infections with retroviruses such as human immunodeficiency virus-1 (HIV-1) and human T lymphotropic virus type 1; and the beneficial effect of anti-retroviral treatment on the occurrence of HIV-1-associated sicca syndrome. Additional evidence is provided by animal models. |
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Venezuela, Bolivarian Republic of | 2 | 100% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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United States | 1 | 3% |
Netherlands | 1 | 3% |
Unknown | 33 | 94% |
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Researcher | 7 | 20% |
Student > Ph. D. Student | 6 | 17% |
Student > Postgraduate | 5 | 14% |
Student > Master | 4 | 11% |
Professor | 4 | 11% |
Other | 5 | 14% |
Unknown | 4 | 11% |
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Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 0 | 0% |
Unknown | 10 | 29% |