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Influencing the secretion of myogenic factors from mesenchymal stem cells

Overview of attention for article published in Stem Cell Research & Therapy, August 2014
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Title
Influencing the secretion of myogenic factors from mesenchymal stem cells
Published in
Stem Cell Research & Therapy, August 2014
DOI 10.1186/scrt485
Pubmed ID
Authors

Lucas R Smith

Abstract

Mounting evidence indicates that the regenerative effect of mesenchymal stem cells in skeletal muscle is related to the secretion of factors that stimulate resident myogenic cells. However, the environmental cues that affect the secreted factors of mesenchymal stem cells are not well understood. A recent publication demonstrated that secretion of factors is dependent on cell substrate, with mesenchymal stem cells grown on laminin providing more pro-myogenic factors than those grown on collagen, and that cellular strain may also play a role. Conditioned media from mesenchymal stem cells grown on laminin and subjected to strain provided the quickest and largest stimulation to myogenic cell proliferation. The influence of cell substrate and mechanical perturbation on mesenchymal stem cells therefore appears key to secretion of factors that support myogenesis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 7%
Russia 1 7%
Unknown 13 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 27%
Student > Master 3 20%
Student > Postgraduate 2 13%
Student > Doctoral Student 2 13%
Researcher 1 7%
Other 3 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 27%
Biochemistry, Genetics and Molecular Biology 3 20%
Medicine and Dentistry 3 20%
Sports and Recreations 1 7%
Mathematics 1 7%
Other 3 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2014.
All research outputs
#6,627,430
of 8,702,492 outputs
Outputs from Stem Cell Research & Therapy
#565
of 757 outputs
Outputs of similar age
#120,904
of 183,252 outputs
Outputs of similar age from Stem Cell Research & Therapy
#13
of 16 outputs
Altmetric has tracked 8,702,492 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 757 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,252 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.