Title |
PVP-coated silver nanoparticles block the transmission of cell-free and cell-associated HIV-1 in human cervical culture
|
---|---|
Published in |
Journal of Nanobiotechnology, July 2010
|
DOI | 10.1186/1477-3155-8-15 |
Pubmed ID | |
Authors |
Humberto H Lara, Liliana Ixtepan-Turrent, Elsa N Garza-Treviño, Cristina Rodriguez-Padilla |
Abstract |
Previous in vitro studies have demonstrated that polyvinylpyrrolidone coated silver nanoparticles (PVP-coated AgNPs) have antiviral activity against HIV-1 at non-cytotoxic concentrations. These particles also demonstrate broad spectrum virucidal activity by preventing the interaction of HIV-1 gp120 and cellular CD4, thereby inhibiting fusion or entry of the virus into the host cell. In this study, we evaluated the antiviral activity of PVP-coated AgNPs as a potential topical vaginal microbicide to prevent transmission of HIV-1 infection using human cervical culture, an in vitro model that simulates in vivo conditions. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Russia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
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United Kingdom | 2 | 1% |
Ireland | 1 | <1% |
Australia | 1 | <1% |
France | 1 | <1% |
South Africa | 1 | <1% |
Bahrain | 1 | <1% |
India | 1 | <1% |
United States | 1 | <1% |
Unknown | 134 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 18% |
Student > Master | 23 | 16% |
Researcher | 20 | 14% |
Student > Bachelor | 13 | 9% |
Student > Doctoral Student | 9 | 6% |
Other | 22 | 15% |
Unknown | 30 | 21% |
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---|---|---|
Agricultural and Biological Sciences | 22 | 15% |
Chemistry | 17 | 12% |
Materials Science | 13 | 9% |
Medicine and Dentistry | 11 | 8% |
Biochemistry, Genetics and Molecular Biology | 10 | 7% |
Other | 34 | 24% |
Unknown | 36 | 25% |