Title |
Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice
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Published in |
Arthritis Research & Therapy, July 2014
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DOI | 10.1186/ar4605 |
Pubmed ID | |
Authors |
Ingrid Lindh, Omri Snir, Erik Lönnblom, Hüseyin Uysal, Ida Andersson, Kutty Selva Nandakumar, Michel Vierboom, Bert 't Hart, Vivianne Malmström, Rikard Holmdahl |
Abstract |
Antibodies towards type II collagen (CII) are detected in patients with rheumatoid arthritis (RA) and in non-human primates and rodents with collagen induced arthritis (CIA). We have previously shown that antibodies specific for several CII-epitopes are pathogenic using monoclonal antibodies from arthritic mice, although the role of different anti-CII epitopes has not been investigated in detail in other species. We therefore performed an inter-species comparative study of the autoantibody response to CII in patients with RA versus monkeys and mice with CIA. |
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