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Mendeley readers
Attention Score in Context
| Title |
High expression of microRNA-130b correlates with poor prognosis of patients with hepatocellular carcinoma
|
|---|---|
| Published in |
Diagnostic Pathology, August 2014
|
| DOI | 10.1186/s13000-014-0160-5 |
| Pubmed ID | |
| Authors |
Wen-yao Wang, Hong-fei Zhang, Lei Wang, Yan-peng Ma, Fei Gao, Shao-jun Zhang, Li-chao Wang |
| Abstract |
BackgroundWhether microRNA-130b(miR-130b) can serve as a prognostic biomarker of hepatocellular carcinoma (HCC) has not been investigated. In the present study, we investigated the feasibility of miR-130b as a novel prognostic biomarker for HCC.MethodsWe retrospectively investigated 97 patients diagnosed with HCC who underwent routine curative surgery between May 2007 and July 2012. miR-130b expression in HCC tissues and paired normal adjacent liver tissues was measured by reverse transcription and real-time PCR (RT-PCR). Survival curves were plotted using the Kaplan-Meier method and differences in survival rates were analyzed using the log-rank test.ResultsmiR-130b expression level was significantly higher in HCC tissues compared with normal adjacent liver tissues (P¿<¿0.0001). The 5-year overall survival (OS) of high miR-130b expression group was significantly shorter than that of low miR-130b expression group(43.6% vs. 71.5%; P¿=¿0.022). Moreover, the 5-year disease-free survival(DFS) of high miR-130b expression group was also significantly shorter than that of low miR-130b expression group (25.9% vs. 63.9%; P¿=¿0.012). In a multivariate Cox model, we found that miR-130b expression was an independent prognostic factor for both 5-year OS (hazards ratio [HR]¿=¿2.523, 95% confidence interval [CI]¿=¿1.024-7.901, P¿=¿0.011) and 5-year DFS (HR¿=¿4.003, CI¿=¿1.578-7.899, P¿=¿0.005) in HCC.ConclusionThe results indicated that high expression of microRNA-130b was correlated with significant characteristics of patients with HCC, and it might be useful as a novel prognostic biomarker for HCC.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_160. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 8% |
| Unknown | 11 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 33% |
| Student > Bachelor | 2 | 17% |
| Student > Ph. D. Student | 2 | 17% |
| Student > Master | 2 | 17% |
| Student > Doctoral Student | 1 | 8% |
| Other | 1 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 50% |
| Biochemistry, Genetics and Molecular Biology | 3 | 25% |
| Agricultural and Biological Sciences | 1 | 8% |
| Nursing and Health Professions | 1 | 8% |
| Unknown | 1 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2014.
All research outputs
#18,376,056
of 22,760,687 outputs
Outputs from Diagnostic Pathology
#758
of 1,122 outputs
Outputs of similar age
#164,492
of 230,675 outputs
Outputs of similar age from Diagnostic Pathology
#22
of 32 outputs
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So far Altmetric has tracked 1,122 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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