Title |
Immunotoxicity of silver nanoparticles in an intravenous 28-day repeated-dose toxicity study in rats
|
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Published in |
Particle and Fibre Toxicology, May 2014
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DOI | 10.1186/1743-8977-11-21 |
Pubmed ID | |
Authors |
Rob J Vandebriel, Elisa CM Tonk, Liset J de la Fonteyne-Blankestijn, Eric R Gremmer, Henny W Verharen, Leo T van der Ven, Henk van Loveren, Wim H de Jong |
Abstract |
Nanosilver is used in a variety of medical and consumer products because of its antibacterial activity. This wide application results in an increased human exposure. Knowledge on the systemic toxicity of nanosilver is, however, relatively scarce. In a previous study, the systemic toxicity of 20 nm silver nanoparticles (Ag-NP) was studied in a 28-day repeated-dose toxicity study in rats. Ag-NP were intravenously administered with a maximum dose of 6 mg/kg body weight (bw)/day. Several immune parameters were affected: reduced thymus weight, increased spleen weight and spleen cell number, a strongly reduced NK cell activity, and reduced IFN-γ production were observed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Hungary | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Korea, Republic of | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 70 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 13 | 18% |
Researcher | 11 | 15% |
Student > Ph. D. Student | 10 | 14% |
Student > Master | 6 | 8% |
Other | 4 | 5% |
Other | 9 | 12% |
Unknown | 20 | 27% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 12 | 16% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Medicine and Dentistry | 5 | 7% |
Immunology and Microbiology | 4 | 5% |
Chemistry | 4 | 5% |
Other | 15 | 21% |
Unknown | 28 | 38% |