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Immunotoxicity of silver nanoparticles in an intravenous 28-day repeated-dose toxicity study in rats

Overview of attention for article published in Particle and Fibre Toxicology, May 2014
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Title
Immunotoxicity of silver nanoparticles in an intravenous 28-day repeated-dose toxicity study in rats
Published in
Particle and Fibre Toxicology, May 2014
DOI 10.1186/1743-8977-11-21
Pubmed ID
Authors

Rob J Vandebriel, Elisa CM Tonk, Liset J de la Fonteyne-Blankestijn, Eric R Gremmer, Henny W Verharen, Leo T van der Ven, Henk van Loveren, Wim H de Jong

Abstract

Nanosilver is used in a variety of medical and consumer products because of its antibacterial activity. This wide application results in an increased human exposure. Knowledge on the systemic toxicity of nanosilver is, however, relatively scarce. In a previous study, the systemic toxicity of 20 nm silver nanoparticles (Ag-NP) was studied in a 28-day repeated-dose toxicity study in rats. Ag-NP were intravenously administered with a maximum dose of 6 mg/kg body weight (bw)/day. Several immune parameters were affected: reduced thymus weight, increased spleen weight and spleen cell number, a strongly reduced NK cell activity, and reduced IFN-γ production were observed.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Korea, Republic of 1 1%
Brazil 1 1%
Unknown 70 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 18%
Researcher 11 15%
Student > Ph. D. Student 10 14%
Student > Master 6 8%
Other 4 5%
Other 9 12%
Unknown 20 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 16%
Biochemistry, Genetics and Molecular Biology 5 7%
Medicine and Dentistry 5 7%
Immunology and Microbiology 4 5%
Chemistry 4 5%
Other 15 21%
Unknown 28 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2015.
All research outputs
#20,656,161
of 25,374,647 outputs
Outputs from Particle and Fibre Toxicology
#492
of 614 outputs
Outputs of similar age
#178,088
of 241,930 outputs
Outputs of similar age from Particle and Fibre Toxicology
#9
of 11 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 614 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,930 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.