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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells
|
|---|---|
| Published in |
Journal for Immunotherapy of Cancer, August 2014
|
| DOI | 10.1186/2051-1426-2-25 |
| Pubmed ID | |
| Authors |
Rachel E Beard, Zhili Zheng, Kiran H Lagisetty, William R Burns, Eric Tran, Stephen M Hewitt, Daniel Abate-Daga, Shannon F Rosati, Howard A Fine, Soldano Ferrone, Steven A Rosenberg, Richard A Morgan |
| Abstract |
The development of immunotherapy has led to significant progress in the treatment of metastatic cancer, including the development of genetic engineering technologies that redirect lymphocytes to recognize and target a wide variety of tumor antigens. Chimeric antigen receptors (CARs) are hybrid proteins combining antibody recognition domains linked to T cell signaling elements. Clinical trials of CAR-transduced peripheral blood lymphocytes (PBL) have induced remission of both solid organ and hematologic malignancies. Chondroitin sulfate proteoglycan 4 (CSPG4) is a promising target antigen that is overexpressed in multiple cancer histologies including melanoma, triple-negative breast cancer, glioblastoma, mesothelioma and sarcoma. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Portugal | 2 | 2% |
| Italy | 1 | <1% |
| Unknown | 120 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 27 | 22% |
| Student > Ph. D. Student | 17 | 14% |
| Student > Master | 16 | 13% |
| Student > Bachelor | 14 | 11% |
| Student > Postgraduate | 6 | 5% |
| Other | 15 | 12% |
| Unknown | 30 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 22% |
| Medicine and Dentistry | 22 | 18% |
| Immunology and Microbiology | 17 | 14% |
| Biochemistry, Genetics and Molecular Biology | 15 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 7 | 6% |
| Unknown | 33 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2022.
All research outputs
#4,196,266
of 25,394,764 outputs
Outputs from Journal for Immunotherapy of Cancer
#1,112
of 3,428 outputs
Outputs of similar age
#39,980
of 247,248 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#3
of 10 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,428 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,248 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.