Title |
Designing of peptides with desired half-life in intestine-like environment
|
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Published in |
BMC Bioinformatics, August 2014
|
DOI | 10.1186/1471-2105-15-282 |
Pubmed ID | |
Authors |
Arun Sharma, Deepak Singla, Mamoon Rashid, Gajendra Pal Singh Raghava |
Abstract |
In past, a number of peptides have been reported to possess highly diverse properties ranging from cell penetrating, tumor homing, anticancer, anti-hypertensive, antiviral to antimicrobials. Owing to their excellent specificity, low-toxicity, rich chemical diversity and availability from natural sources, FDA has successfully approved a number of peptide-based drugs and several are in various stages of drug development. Though peptides are proven good drug candidates, their usage is still hindered mainly because of their high susceptibility towards proteases degradation. We have developed an in silico method to predict the half-life of peptides in intestine-like environment and to design better peptides having optimized physicochemical properties and half-life. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 50% |
Norway | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 2 | 2% |
Germany | 1 | <1% |
Unknown | 105 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 19% |
Student > Master | 15 | 14% |
Researcher | 13 | 12% |
Student > Bachelor | 10 | 9% |
Student > Doctoral Student | 7 | 6% |
Other | 14 | 13% |
Unknown | 28 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 30 | 28% |
Biochemistry, Genetics and Molecular Biology | 22 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
Chemistry | 6 | 6% |
Immunology and Microbiology | 4 | 4% |
Other | 11 | 10% |
Unknown | 29 | 27% |