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Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution

Overview of attention for article published in Biology Direct, January 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters
patent
2 patents
f1000
1 research highlight platform

Citations

dimensions_citation
120 Dimensions

Readers on

mendeley
190 Mendeley
citeulike
8 CiteULike
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Title
Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution
Published in
Biology Direct, January 2007
DOI 10.1186/1745-6150-2-17
Pubmed ID
Authors

Jesse D Bloom, Philip A Romero, Zhongyi Lu, Frances H Arnold

Abstract

Many of the mutations accumulated by naturally evolving proteins are neutral in the sense that they do not significantly alter a protein's ability to perform its primary biological function. However, new protein functions evolve when selection begins to favor other, "promiscuous" functions that are incidental to a protein's original biological role. If mutations that are neutral with respect to a protein's primary biological function cause substantial changes in promiscuous functions, these mutations could enable future functional evolution.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 3%
Belgium 2 1%
Australia 1 <1%
Norway 1 <1%
France 1 <1%
Brazil 1 <1%
Canada 1 <1%
Netherlands 1 <1%
Switzerland 1 <1%
Other 1 <1%
Unknown 175 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 62 33%
Researcher 54 28%
Student > Master 16 8%
Student > Bachelor 12 6%
Student > Doctoral Student 8 4%
Other 24 13%
Unknown 14 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 83 44%
Biochemistry, Genetics and Molecular Biology 45 24%
Chemistry 21 11%
Engineering 7 4%
Physics and Astronomy 4 2%
Other 13 7%
Unknown 17 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2014.
All research outputs
#1,613,630
of 15,922,988 outputs
Outputs from Biology Direct
#88
of 582 outputs
Outputs of similar age
#22,482
of 202,325 outputs
Outputs of similar age from Biology Direct
#2
of 5 outputs
Altmetric has tracked 15,922,988 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 582 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 202,325 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.