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Factors associated with syphilis treatment failure and reinfection: a longitudinal cohort study in Shenzhen, China

Overview of attention for article published in BMC Infectious Diseases, September 2017
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Title
Factors associated with syphilis treatment failure and reinfection: a longitudinal cohort study in Shenzhen, China
Published in
BMC Infectious Diseases, September 2017
DOI 10.1186/s12879-017-2715-z
Pubmed ID
Authors

Zhenzhou Luo, Lin Zhu, Yi Ding, Jun Yuan, Wu Li, Qiuhong Wu, Lishan Tian, Li Zhang, Guomao Zhou, Tao Zhang, Jianping Ma, Zhongwei Chen, Tubao Yang, Tiejian Feng, Min Zhang

Abstract

The treatment failure and reinfection rates among syphilis patients are high, and relevant studies in China are limited. The aim of this study was to detect the rates of treatment failure and reinfection after syphilis treatment and to explore the potential associated factors. We conducted a longitudinal cohort study in a sexually transmitted disease clinic, the Department of Dermatology and Venereology in Nanshan Center for Chronic Disease Control. Serological testing was performed at baseline and throughout the 2-year follow-up for syphilis patients. To identify potential predictors of treatment outcomes, multivariate logistics analyses were utilized to compare the demographic and clinical characteristics of patients with serological failure/reinfection to those with serological cure/serofast. From June 2011 to June 2016, a total of 1133 patients were screened for syphilis. Among the 770 patients who completed the 2-year follow-up, 510 first-diagnosed patients were included in the final analysis. Multivariate logistics analysis revealed the stage of syphilis (secondary syphilis VS. primary syphilis: adjusted odds ratio, 3.50; 95% confidence interval, 1.11-15.47; p = 0.04), HIV status (positive VS. negative: adjusted odds ratio, 3.06; 95% confidence interval, 1.15-8.04; p = 0.02) and frequency of condom use (always use VS. never use: adjusted odds ratio, 0.28; 95% confidence interval 0.08-0.75; p = 0.02) were significantly associated with the serological outcome. The clinical implications of our findings suggest that it is very important to perform regular clinical and serologic evaluations after treatment. Health counseling and safety education on sex activity should be intensified among HIV-infected patients and secondary syphilis patients after treatment.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 15%
Student > Bachelor 8 13%
Other 6 10%
Student > Master 6 10%
Student > Postgraduate 4 6%
Other 7 11%
Unknown 22 35%
Readers by discipline Count As %
Medicine and Dentistry 15 24%
Biochemistry, Genetics and Molecular Biology 5 8%
Agricultural and Biological Sciences 3 5%
Nursing and Health Professions 3 5%
Immunology and Microbiology 2 3%
Other 9 15%
Unknown 25 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2019.
All research outputs
#15,479,632
of 23,002,898 outputs
Outputs from BMC Infectious Diseases
#4,528
of 7,720 outputs
Outputs of similar age
#198,576
of 316,290 outputs
Outputs of similar age from BMC Infectious Diseases
#90
of 150 outputs
Altmetric has tracked 23,002,898 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,720 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,290 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 150 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.