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An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines

Overview of attention for article published in BMC Genomics, August 2014
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Title
An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines
Published in
BMC Genomics, August 2014
DOI 10.1186/1471-2164-15-711
Pubmed ID
Authors

Sebastian F Vencken, Praveen Sethupathy, Gordon Blackshields, Cathy Spillane, Salah Elbaruni, Orla Sheils, Michael F Gallagher, John J O’Leary

Abstract

SOX2 is a core component of the transcriptional network responsible for maintaining embryonal carcinoma cells (ECCs) in a pluripotent, undifferentiated state of self-renewal. As such, SOX2 is an oncogenic transcription factor and crucial cancer stem cell (CSC) biomarker in embryonal carcinoma and, as more recently found, in the stem-like cancer cell component of many other malignancies. SOX2 is furthermore a crucial factor in the maintenance of adult stem cell phenotypes and has additional roles in cell fate determination. The SOX2-linked microRNA (miRNA) transcriptome and regulome has not yet been fully defined in human pluripotent cells or CSCs. To improve our understanding of the SOX2-linked miRNA regulatory network as a contribution to the phenotype of these cell types, we used high-throughput differential miRNA and gene expression analysis combined with existing genome-wide SOX2 chromatin immunoprecipitation (ChIP) data to map the SOX2 miRNA transcriptome in two human embryonal carcinoma cell (hECC) lines.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
France 1 2%
Unknown 44 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 20%
Student > Ph. D. Student 9 20%
Student > Bachelor 8 17%
Researcher 7 15%
Student > Postgraduate 3 7%
Other 5 11%
Unknown 5 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 35%
Agricultural and Biological Sciences 13 28%
Medicine and Dentistry 7 15%
Social Sciences 1 2%
Psychology 1 2%
Other 0 0%
Unknown 8 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2014.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from BMC Genomics
#8,709
of 11,244 outputs
Outputs of similar age
#180,879
of 247,266 outputs
Outputs of similar age from BMC Genomics
#204
of 271 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,244 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 271 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.