Title |
Metastatic tumor evolution and organoid modeling implicate TGFBR2as a cancer driver in diffuse gastric cancer
|
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Published in |
Genome Biology, August 2014
|
DOI | 10.1186/s13059-014-0428-9 |
Pubmed ID | |
Authors |
Lincoln D Nadauld, Sarah Garcia, Georges Natsoulis, John M Bell, Laura Miotke, Erik S Hopmans, Hua Xu, Reetesh K Pai, Curt Palm, John F Regan, Hao Chen, Patrick Flaherty, Akifumi Ootani, Nancy R Zhang, James M Ford, Calvin J Kuo, Hanlee P Ji |
Abstract |
Gastric cancer is the second-leading cause of global cancer deaths, with metastatic disease representing the primary cause of mortality. To identify candidate drivers involved in oncogenesis and tumor evolution, we conduct an extensive genome sequencing analysis of metastatic progression in a diffuse gastric cancer. This involves a comparison between a primary tumor from a hereditary diffuse gastric cancer syndrome proband and its recurrence as an ovarian metastasis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 29% |
Brazil | 1 | 14% |
Italy | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 43% |
Scientists | 2 | 29% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Germany | 1 | <1% |
United Kingdom | 1 | <1% |
Austria | 1 | <1% |
Canada | 1 | <1% |
Poland | 1 | <1% |
Unknown | 155 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 33 | 20% |
Researcher | 22 | 14% |
Student > Master | 20 | 12% |
Student > Bachelor | 17 | 10% |
Other | 13 | 8% |
Other | 26 | 16% |
Unknown | 31 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 44 | 27% |
Biochemistry, Genetics and Molecular Biology | 34 | 21% |
Medicine and Dentistry | 23 | 14% |
Engineering | 6 | 4% |
Mathematics | 5 | 3% |
Other | 18 | 11% |
Unknown | 32 | 20% |