Title |
Assessment of Toll-like receptor 2, 4 and 9 SNP genotypes in canine sino-nasal aspergillosis
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Published in |
BMC Veterinary Research, August 2014
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DOI | 10.1186/s12917-014-0187-6 |
Pubmed ID | |
Authors |
Elise Mercier, Iain R Peters, Frédéric Farnir, Rachel Lavoué, Michael Day, Cécile Clercx, Dominique Peeters |
Abstract |
The exact aetiology of canine sino-nasal aspergillosis (SNA) is unknown. In man, dysfunction in innate immunity, particularly in the function of pattern recognition receptors, is implicated in the pathogenesis of inflammatory sino-nasal disease and in fungal diseases. Associations between single nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) and these diseases have been identified. Similarly, in dogs SNPs in genes encoding TLRs may be important in the pathogenesis of SNA. The aims of the present study were (1) to identify the presence of non-synonymous SNPs in the coding regions of the TLR2, 4 and 9 genes in dogs suffering from SNA, and (2) to investigate the SNP genotypes in dogs with SNA compared with a control population. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 24% |
Researcher | 3 | 18% |
Student > Master | 3 | 18% |
Other | 2 | 12% |
Professor | 1 | 6% |
Other | 1 | 6% |
Unknown | 3 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 29% |
Veterinary Science and Veterinary Medicine | 3 | 18% |
Agricultural and Biological Sciences | 3 | 18% |
Biochemistry, Genetics and Molecular Biology | 3 | 18% |
Unknown | 3 | 18% |