Title |
Recombinant Lactococcus lactis can make the difference in antigen-specific immune tolerance induction, the Type 1 Diabetes case
|
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Published in |
Microbial Cell Factories, January 2014
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DOI | 10.1186/1475-2859-13-s1-s11 |
Pubmed ID | |
Authors |
Sofie Robert, Lothar Steidler |
Abstract |
Especially in western civilizations, immune diseases that are driven by innocuous (auto- or allo-) antigens are gradually evolving to become pandemic threats. A particularly poignant example is type 1 diabetes, where young children are confronted with the perspective and consequences of total pancreatic β-cell destruction. Along these disquieting observations we find ourselves equipped with impressively accumulating molecular immunological knowledge on the ins and outs of these pathologies. Often, however, it is difficult to translate this wealth into efficacious medicines. The molecular understanding, the concept of oral tolerance induction, the benefit of using recombinant Lactococcus lactis therein and recent openings towards their clinical use may well enable turning all colors to their appropriate fields on this Rubik's cube. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 61 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 10 | 16% |
Student > Master | 8 | 13% |
Researcher | 7 | 11% |
Student > Doctoral Student | 6 | 10% |
Student > Postgraduate | 5 | 8% |
Other | 10 | 16% |
Unknown | 15 | 25% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 13 | 21% |
Medicine and Dentistry | 10 | 16% |
Agricultural and Biological Sciences | 9 | 15% |
Engineering | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 7 | 11% |
Unknown | 17 | 28% |