Title |
Serotype-conversion in Shigella flexneri:identification of a novel bacteriophage, Sf101, from a serotype 7a strain
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Published in |
BMC Genomics, August 2014
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DOI | 10.1186/1471-2164-15-742 |
Pubmed ID | |
Authors |
Richa Jakhetia, Aruna Marri, Jonas Ståhle, Göran Widmalm, Naresh K Verma |
Abstract |
Shigella flexneri is the major cause of bacillary dysentery in the developing countries. The lipopolysaccharide (LPS) O-antigen of S. flexneri plays an important role in its pathogenesis and also divides S. flexneri into 19 serotypes. All the serotypes with an exception for serotype 6 share a common O-antigen backbone comprising of N-acetylglucosamine and three rhamnose residues. Different serotypes result from modification of the basic backbone conferred by phage-encoded glucosyltransferase and/or acetyltransferase genes, or plasmid-encoded phosphoethanolamine transferase. Recently, a new site for O-acetylation at positions 3 and 4 of RhaIII, in serotypes 1a, 1b, 2a, 5a and Y was shown to be mediated by the oacB gene. Additionally, this gene was shown to be carried by a transposon-like structure inserted upstream of the adrA region on the chromosome. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 50% |
Members of the public | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
Unknown | 28 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 21% |
Student > Ph. D. Student | 4 | 14% |
Student > Master | 4 | 14% |
Student > Bachelor | 3 | 10% |
Student > Doctoral Student | 1 | 3% |
Other | 3 | 10% |
Unknown | 8 | 28% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 10 | 34% |
Biochemistry, Genetics and Molecular Biology | 4 | 14% |
Immunology and Microbiology | 2 | 7% |
Chemistry | 2 | 7% |
Environmental Science | 1 | 3% |
Other | 2 | 7% |
Unknown | 8 | 28% |