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Protecting effect of PrP codons M142 and K222 in goats orally challenged with bovine spongiform encephalopathy prions

Overview of attention for article published in Veterinary Research, September 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)

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1 policy source
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2 tweeters

Citations

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10 Dimensions

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12 Mendeley

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Title
Protecting effect of PrP codons M142 and K222 in goats orally challenged with bovine spongiform encephalopathy prions
Published in
Veterinary Research, September 2017
DOI 10.1186/s13567-017-0455-0
Pubmed ID
28927447
Authors

C. Fast, W. Goldmann, P. Berthon, K. Tauscher, O. Andréoletti, I. Lantier, C. Rossignol, A. Bossers, J. G. Jacobs, N. Hunter, M. H. Groschup, F. Lantier, J. P. M. Langeveld, Fast, C, Wilfred Goldmann, Berthon, P, Tauscher, K, Andréoletti, O, Lantier, I, Rossignol, C, Bossers, A, Jane Jacobs, Nicola Hunter, Groschup, M H, Lantier, F, Langeveld, J P M

Abstract

Breeding towards genetic resistance to prion disease is effective in eliminating scrapie. In sheep, classical forms of scrapie have been eradicated almost completely in several countries by breeding programs using a prion protein (PrP) gene (PRNP) amino acid polymorphism. For goats, field and experimental studies have provided evidence for several amino acid polymorphisms that are associated with resistance to scrapie, but only limited data are available concerning the susceptibility of caprine PRNP genotypes to BSE. In this study, goat kids representing five PRNP genotypes based on three polymorphisms (M142, Q211 and K222 and the wild type I142, R211 and Q222) were orally challenged with bovine or goat BSE. Wild type goats were killed with clinical signs between 24-28 months post inoculation (mpi) to both challenges, and goats with genotype R/Q211 succumbed between 29-36 mpi. I/M142 goats developed clinical signs at 44-45 mpi and M/M142 goats remained healthy until euthanasia at 48 mpi. None of the Q/K222 goats showed definite clinical signs. Taken together the highest attack ratios were seen in wild type and R/Q211 goats, and the lowest in I/M142, M/M142 and Q/K222. In all genotype groups, one or more goats remained healthy within the incubation period in both challenges and without detectable PrP deposition in the tissues. Our data show that both the K222 and M142 polymorphisms lengthen the incubation period significantly compared to wild type animals, but only K222 was associated with a significant increase in resistance to BSE infection after oral exposure to both BSE sources.

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Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 33%
Researcher 3 25%
Other 2 17%
Student > Doctoral Student 1 8%
Student > Master 1 8%
Other 1 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 33%
Veterinary Science and Veterinary Medicine 2 17%
Unspecified 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Immunology and Microbiology 1 8%
Other 2 17%
Unknown 1 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2018.
All research outputs
#5,988,690
of 20,275,020 outputs
Outputs from Veterinary Research
#273
of 1,098 outputs
Outputs of similar age
#96,818
of 292,016 outputs
Outputs of similar age from Veterinary Research
#1
of 4 outputs
Altmetric has tracked 20,275,020 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,098 research outputs from this source. They receive a mean Attention Score of 4.5. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,016 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them

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