Title |
Genomic imprinting of IGF2 in marsupials is methylation dependent
|
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Published in |
BMC Genomics, May 2008
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DOI | 10.1186/1471-2164-9-205 |
Pubmed ID | |
Authors |
Betty R Lawton, Benjamin R Carone, Craig J Obergfell, Gianni C Ferreri, Christina M Gondolphi, John L VandeBerg, Ikhide Imumorin, Rachel J O'Neill, Michael J O'Neill |
Abstract |
Parent-specific methylation of specific CpG residues is critical to imprinting in eutherian mammals, but its importance to imprinting in marsupials and, thus, the evolutionary origins of the imprinting mechanism have been the subject of controversy. This has been particularly true for the imprinted Insulin-like Growth Factor II (IGF2), a key regulator of embryonic growth in vertebrates and a focal point of the selective forces leading to genomic imprinting. The presence of the essential imprinting effector, DNMT3L, in marsupial genomes and the demonstration of a differentially methylated region (DMR) in the retrotransposon-derived imprinted gene, PEG10, in tammar wallaby argue for a role for methylation in imprinting, but several studies have found no evidence of parent-specific methylation at other imprinted loci in marsupials. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
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United States | 1 | 2% |
Czechia | 1 | 2% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 24% |
Student > Ph. D. Student | 9 | 21% |
Student > Master | 5 | 12% |
Professor | 5 | 12% |
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Other | 8 | 19% |
Unknown | 2 | 5% |
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Unspecified | 2 | 5% |
Neuroscience | 2 | 5% |
Other | 1 | 2% |
Unknown | 4 | 10% |