Title |
Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine
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Published in |
Malaria Journal, April 2013
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DOI | 10.1186/1475-2875-12-136 |
Pubmed ID | |
Authors |
Margaret E McCoy, Hannah E Golden, Tais APF Doll, Yongkun Yang, Stephen A Kaba, Peter Burkhard, David E Lanar |
Abstract |
A lack of defined correlates of immunity for malaria, combined with the inability to induce long-lived sterile immune responses in a human host, demonstrate a need for improved understanding of potentially protective immune mechanisms for enhanced vaccine efficacy. Protective sterile immunity (>90%) against the Plasmodium falciparum circumsporozoite protein (CSP) has been achieved using a transgenically modified Plasmodium berghei sporozoite (Tg-Pb/PfCSP) and a self-assembling protein nanoparticle (SAPN) vaccine presenting CSP epitopes (PfCSP-SAPN). Here, several possible mechanisms involved in the independently protective humoral and cellular responses induced following SAPN immunization are described. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Spain | 1 | 2% |
France | 1 | 2% |
Unknown | 62 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 25% |
Student > Master | 12 | 18% |
Researcher | 11 | 17% |
Student > Bachelor | 6 | 9% |
Lecturer | 4 | 6% |
Other | 13 | 20% |
Unknown | 3 | 5% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 14% |
Biochemistry, Genetics and Molecular Biology | 6 | 9% |
Immunology and Microbiology | 4 | 6% |
Social Sciences | 3 | 5% |
Other | 13 | 20% |
Unknown | 4 | 6% |