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Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine

Overview of attention for article published in Malaria Journal, April 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
3 news outlets
blogs
1 blog
googleplus
2 Google+ users

Citations

dimensions_citation
47 Dimensions

Readers on

mendeley
65 Mendeley
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Title
Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine
Published in
Malaria Journal, April 2013
DOI 10.1186/1475-2875-12-136
Pubmed ID
Authors

Margaret E McCoy, Hannah E Golden, Tais APF Doll, Yongkun Yang, Stephen A Kaba, Peter Burkhard, David E Lanar

Abstract

A lack of defined correlates of immunity for malaria, combined with the inability to induce long-lived sterile immune responses in a human host, demonstrate a need for improved understanding of potentially protective immune mechanisms for enhanced vaccine efficacy. Protective sterile immunity (>90%) against the Plasmodium falciparum circumsporozoite protein (CSP) has been achieved using a transgenically modified Plasmodium berghei sporozoite (Tg-Pb/PfCSP) and a self-assembling protein nanoparticle (SAPN) vaccine presenting CSP epitopes (PfCSP-SAPN). Here, several possible mechanisms involved in the independently protective humoral and cellular responses induced following SAPN immunization are described.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
France 1 2%
Unknown 62 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 25%
Student > Master 12 18%
Researcher 11 17%
Student > Bachelor 6 9%
Lecturer 4 6%
Other 13 20%
Unknown 3 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 40%
Medicine and Dentistry 9 14%
Biochemistry, Genetics and Molecular Biology 6 9%
Immunology and Microbiology 4 6%
Social Sciences 3 5%
Other 13 20%
Unknown 4 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2014.
All research outputs
#1,148,818
of 22,763,032 outputs
Outputs from Malaria Journal
#178
of 5,554 outputs
Outputs of similar age
#9,571
of 196,539 outputs
Outputs of similar age from Malaria Journal
#3
of 75 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,554 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,539 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.