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Is Graves’ disease a primary immunodeficiency? New immunological perspectives on an endocrine disease

Overview of attention for article published in BMC Medicine, September 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)

Mentioned by

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5 tweeters

Citations

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12 Dimensions

Readers on

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79 Mendeley
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Title
Is Graves’ disease a primary immunodeficiency? New immunological perspectives on an endocrine disease
Published in
BMC Medicine, September 2017
DOI 10.1186/s12916-017-0939-9
Pubmed ID
Authors

Tristan Struja, Alexander Kutz, Stefan Fischli, Christian Meier, Beat Mueller, Mike Recher, Philipp Schuetz

Abstract

Uncertainty about factors influencing the susceptibility and triggers for Graves' disease persists, along with a wide variation in the response to anti-thyroid drugs, currently at approximately 50% of non-responders. The aim of this narrative review is to summarize immunological concepts, with a combined endocrine and immunological perspective, to highlight potential new areas of research. Relevant studies were identified through a systematic literature search using the PubMed and EMBASE databases in March 2016. No cut-offs regarding dates were imposed. We used the terms "Graves' Disease" or "Basedow" or "thyrotoxicosis" together with the terms "etiology", "pathophysiology", "immunodeficiency", "causality", and "autoimmunity". The terms "orbitopathy", "ophthalmopathy", and "amiodarone" were excluded. Articles in English, French, German, Croatian, Spanish, and Italian were eligible for inclusion. While concepts such as the impact of iodine, smoking, human leucocyte antigen, infections, and ethnicity are established, new ideas have emerged. Pertaining evidence suggests the involvement of autoimmunity and immunodeficiency in the pathophysiology of Graves' disease. Recent studies point to specific immunological mechanisms triggering the onset of disease, which may also serve as targets for more specific therapies.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 79 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 20%
Researcher 9 11%
Student > Master 7 9%
Student > Doctoral Student 5 6%
Student > Ph. D. Student 5 6%
Other 15 19%
Unknown 22 28%
Readers by discipline Count As %
Medicine and Dentistry 35 44%
Immunology and Microbiology 4 5%
Nursing and Health Professions 4 5%
Biochemistry, Genetics and Molecular Biology 4 5%
Agricultural and Biological Sciences 3 4%
Other 6 8%
Unknown 23 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2021.
All research outputs
#10,832,129
of 19,509,823 outputs
Outputs from BMC Medicine
#2,380
of 2,904 outputs
Outputs of similar age
#127,500
of 290,470 outputs
Outputs of similar age from BMC Medicine
#1
of 1 outputs
Altmetric has tracked 19,509,823 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,904 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.4. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,470 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them