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Is Graves’ disease a primary immunodeficiency? New immunological perspectives on an endocrine disease

Overview of attention for article published in BMC Medicine, September 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)

Mentioned by

1 news outlet
5 tweeters


15 Dimensions

Readers on

87 Mendeley
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Is Graves’ disease a primary immunodeficiency? New immunological perspectives on an endocrine disease
Published in
BMC Medicine, September 2017
DOI 10.1186/s12916-017-0939-9
Pubmed ID

Tristan Struja, Alexander Kutz, Stefan Fischli, Christian Meier, Beat Mueller, Mike Recher, Philipp Schuetz


Uncertainty about factors influencing the susceptibility and triggers for Graves' disease persists, along with a wide variation in the response to anti-thyroid drugs, currently at approximately 50% of non-responders. The aim of this narrative review is to summarize immunological concepts, with a combined endocrine and immunological perspective, to highlight potential new areas of research. Relevant studies were identified through a systematic literature search using the PubMed and EMBASE databases in March 2016. No cut-offs regarding dates were imposed. We used the terms "Graves' Disease" or "Basedow" or "thyrotoxicosis" together with the terms "etiology", "pathophysiology", "immunodeficiency", "causality", and "autoimmunity". The terms "orbitopathy", "ophthalmopathy", and "amiodarone" were excluded. Articles in English, French, German, Croatian, Spanish, and Italian were eligible for inclusion. While concepts such as the impact of iodine, smoking, human leucocyte antigen, infections, and ethnicity are established, new ideas have emerged. Pertaining evidence suggests the involvement of autoimmunity and immunodeficiency in the pathophysiology of Graves' disease. Recent studies point to specific immunological mechanisms triggering the onset of disease, which may also serve as targets for more specific therapies.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 87 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 18%
Researcher 8 9%
Student > Master 7 8%
Student > Ph. D. Student 6 7%
Other 6 7%
Other 16 18%
Unknown 28 32%
Readers by discipline Count As %
Medicine and Dentistry 36 41%
Biochemistry, Genetics and Molecular Biology 4 5%
Nursing and Health Professions 4 5%
Immunology and Microbiology 4 5%
Agricultural and Biological Sciences 3 3%
Other 8 9%
Unknown 28 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2022.
All research outputs
of 22,522,311 outputs
Outputs from BMC Medicine
of 3,372 outputs
Outputs of similar age
of 298,240 outputs
Outputs of similar age from BMC Medicine
of 1 outputs
Altmetric has tracked 22,522,311 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,372 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.6. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,240 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them