Title |
Role of microRNAs in obesity and obesity-related diseases
|
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Published in |
Genes & Nutrition, September 2017
|
DOI | 10.1186/s12263-017-0577-z |
Pubmed ID | |
Authors |
Giuseppe Iacomino, Alfonso Siani |
Abstract |
In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in maintaining/altering physiological processes, including energy balance and metabolic homeostasis. Altered miRNAs expression has been reported in association with obesity, both in animal and human studies. Dysregulation of miRNAs may affect the status and functions of different tissues and organs, including the adipose tissue, pancreas, liver, and muscle, possibly contributing to metabolic abnormalities associated with obesity and obesity-related diseases. More recently, the discovery of circulating miRNAs easily detectable in plasma and other body fluids has emphasized their potential as both endocrine signaling molecules and disease indicators. In this review, the status of current research on the role of miRNAs in obesity and related metabolic abnormalities is summarized and discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 60% |
United States | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Members of the public | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 200 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 34 | 17% |
Student > Ph. D. Student | 32 | 16% |
Student > Master | 31 | 16% |
Researcher | 16 | 8% |
Student > Doctoral Student | 10 | 5% |
Other | 26 | 13% |
Unknown | 51 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 61 | 31% |
Medicine and Dentistry | 19 | 10% |
Agricultural and Biological Sciences | 16 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 4% |
Nursing and Health Professions | 7 | 4% |
Other | 30 | 15% |
Unknown | 59 | 30% |