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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cyclin-dependent kinases
|
|---|---|
| Published in |
Genome Biology, June 2014
|
| DOI | 10.1186/gb4184 |
| Pubmed ID | |
| Authors |
Marcos Malumbres |
| Abstract |
Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. The evolutionary expansion of the CDK family in mammals led to the division of CDKs into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20). Unlike the prototypical Cdc28 kinase of budding yeast, most of these CDKs bind one or a few cyclins, consistent with functional specialization during evolution. This review summarizes how, although CDKs are traditionally separated into cell-cycle or transcriptional CDKs, these activities are frequently combined in many family members. Not surprisingly, deregulation of this family of proteins is a hallmark of several diseases, including cancer, and drug-targeted inhibition of specific members has generated very encouraging results in clinical trials. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 20% |
| Germany | 1 | 7% |
| Japan | 1 | 7% |
| United Kingdom | 1 | 7% |
| France | 1 | 7% |
| Unknown | 8 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 73% |
| Scientists | 3 | 20% |
| Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,345 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | <1% |
| United States | 2 | <1% |
| France | 1 | <1% |
| Austria | 1 | <1% |
| Netherlands | 1 | <1% |
| India | 1 | <1% |
| Portugal | 1 | <1% |
| Egypt | 1 | <1% |
| Brazil | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 1333 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 270 | 20% |
| Student > Bachelor | 215 | 16% |
| Student > Master | 187 | 14% |
| Researcher | 125 | 9% |
| Student > Doctoral Student | 57 | 4% |
| Other | 136 | 10% |
| Unknown | 355 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 458 | 34% |
| Agricultural and Biological Sciences | 229 | 17% |
| Medicine and Dentistry | 75 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 58 | 4% |
| Chemistry | 55 | 4% |
| Other | 94 | 7% |
| Unknown | 376 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2024.
All research outputs
#1,089,483
of 25,714,183 outputs
Outputs from Genome Biology
#772
of 4,505 outputs
Outputs of similar age
#10,385
of 242,640 outputs
Outputs of similar age from Genome Biology
#9
of 58 outputs
Altmetric has tracked 25,714,183 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,505 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,640 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.