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Mendeley readers
Attention Score in Context
| Title |
The common inflammatory etiology of depression and cognitive impairment: a therapeutic target
|
|---|---|
| Published in |
Journal of Neuroinflammation, September 2014
|
| DOI | 10.1186/s12974-014-0151-1 |
| Pubmed ID | |
| Authors |
David J Allison, David S Ditor |
| Abstract |
Chronic inflammation has been shown to contribute to the development of a wide variety of disorders by means of a number of proposed mechanisms. Depression and cognitive impairment are two such disorders which may share a closely linked inflammatory etiology. The ability of inflammatory mediators to alter the activity of enzymes, from key metabolic pathways, may help explain the connection between these disorders. The chronic up-regulation of the kynurenine pathway results in an imbalance in critical neuroactive compounds involving the reduction of tryptophan and elevation of tryptophan metabolites. Such imbalances have established implications in both depression and cognitive impairment. This may implicate the immune system as a potential therapeutic target in the treatment of these disorders. The most common treatment modalities currently utilized, involve drug interventions which act on downstream targets. Such treatments help to reestablish protein balances, but fail to treat the inflammatory basis of the disorder. The use of anti-inflammatory interventions, such as regular exercise, may therefore, contribute to the effectiveness of current drug interventions in the treatment of both depression and cognitive impairment. |
Mendeley readers
The data shown below were compiled from readership statistics for 234 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 2 | <1% |
| Portugal | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 230 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 37 | 16% |
| Student > Bachelor | 35 | 15% |
| Student > Master | 32 | 14% |
| Student > Ph. D. Student | 31 | 13% |
| Student > Doctoral Student | 15 | 6% |
| Other | 37 | 16% |
| Unknown | 47 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 18% |
| Neuroscience | 28 | 12% |
| Agricultural and Biological Sciences | 25 | 11% |
| Psychology | 21 | 9% |
| Biochemistry, Genetics and Molecular Biology | 15 | 6% |
| Other | 44 | 19% |
| Unknown | 58 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2018.
All research outputs
#3,164,045
of 22,763,032 outputs
Outputs from Journal of Neuroinflammation
#634
of 2,621 outputs
Outputs of similar age
#34,648
of 237,378 outputs
Outputs of similar age from Journal of Neuroinflammation
#5
of 33 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,621 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,378 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.