Title |
Bereavement reduces neutrophil oxidative burst only in older adults: role of the HPA axis and immunesenescence
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Published in |
Immunity & Ageing, August 2014
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DOI | 10.1186/1742-4933-11-13 |
Pubmed ID | |
Authors |
Ana Vitlic, Riyad Khanfer, Janet M Lord, Douglas Carroll, Anna C Phillips |
Abstract |
The effect of the chronic stress of bereavement on immunity is poorly understood. Previous studies have demonstrated negative effects on immunity in older adults, and those who report higher depressive symptoms. The aim of the present study was to compare the effect of bereavement on neutrophil function in healthy young and old adults, also assessing serum levels of the stress hormones, cortisol and dehydroepiandrosterone sulphate (DHEAS). 41 young (mean age 32 years) and 52 older adults (mean age 72 years), bereaved and non-bereaved, took part in the study. They completed questionnaires on socio-demographic and health behaviour characteristics, as well as psychosocial variables, and provided a blood sample for analysis of neutrophil function (phagocytosis and reactive oxygen species (ROS) production) and stress hormone analysis. |
X Demographics
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United States | 1 | 33% |
Demographic breakdown
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Scientists | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
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Brazil | 1 | 2% |
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Student > Master | 11 | 18% |
Student > Bachelor | 11 | 18% |
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Unknown | 14 | 23% |
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Social Sciences | 3 | 5% |
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Unknown | 16 | 26% |