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Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism

Overview of attention for article published in Journal of Inflammation, January 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)

Mentioned by

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3 tweeters

Citations

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83 Dimensions

Readers on

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123 Mendeley
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Title
Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism
Published in
Journal of Inflammation, January 2014
DOI 10.1186/1476-9255-11-23
Pubmed ID
Authors

Srabani Pal, Ashish Bhattacharjee, Asif Ali, Narayan C Mandal, Subhash C Mandal, Mahadeb Pal

Abstract

Activation of nuclear factor-kappa B (NF- κB) as a mechanism of host defense against infection and stress is the central mediator of inflammatory responses. A normal (acute) inflammatory response is activated on urgent basis and is auto-regulated. Chronic inflammation that results due to failure in the regulatory mechanism, however, is largely considered as a critical determinant in the initiation and progression of various forms of cancer. Mechanistically, NF- κB favors this process by inducing various genes responsible for cell survival, proliferation, migration, invasion while at the same time antagonizing growth regulators including tumor suppressor p53. It has been shown by various independent investigations that a down regulation of NF- κB activity directly, or indirectly through the activation of the p53 pathway reduces tumor growth substantially. Therefore, there is a huge effort driven by many laboratories to understand the NF- κB signaling pathways to intervene the function of this crucial player in inflammation and tumorigenesis in order to find an effective inhibitor directly, or through the p53 tumor suppressor. We discuss here on the role of NF- κB in chronic inflammation and cancer, highlighting mutual antagonism between NF- κB and p53 pathways in the process. We also discuss prospective pharmacological modulators of these two pathways, including those that were already tested to affect this mutual antagonism.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 2 2%
Germany 1 <1%
Unknown 120 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 24%
Student > Bachelor 21 17%
Student > Master 16 13%
Researcher 13 11%
Student > Doctoral Student 9 7%
Other 21 17%
Unknown 13 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 32 26%
Medicine and Dentistry 28 23%
Biochemistry, Genetics and Molecular Biology 17 14%
Pharmacology, Toxicology and Pharmaceutical Science 8 7%
Neuroscience 4 3%
Other 16 13%
Unknown 18 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2017.
All research outputs
#6,938,967
of 12,499,297 outputs
Outputs from Journal of Inflammation
#87
of 249 outputs
Outputs of similar age
#80,732
of 202,510 outputs
Outputs of similar age from Journal of Inflammation
#1
of 1 outputs
Altmetric has tracked 12,499,297 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 249 research outputs from this source. They receive a mean Attention Score of 2.5. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 202,510 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them