Title |
CDH1 polymorphisms and haplotypes in sporadic diffuse and intestinal gastric cancer: a case–control study based on direct sequencing analysis
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Published in |
World Journal of Surgical Oncology, March 2014
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DOI | 10.1186/1477-7819-12-80 |
Pubmed ID | |
Authors |
Chi-Ming Chu, Cheng-Jueng Chen, De-Chuan Chan, Hurng-Sheng Wu, Yao-Chi Liu, Chen-Yang Shen, Tzu-Ming Chang, Jyh-cherng Yu, Horng-Jyh Harn, Cheng-Ping Yu, Ming-Hsin Yang |
Abstract |
Findings related to the influence of the -160C → A promoter polymorphism and haplotypes of the E-cadherin (CDH1) gene have not been consistent in previous studies regarding the risk for sporadic gastric cancer. Investigators in most previous studies detected those genotypes using restriction fragment length polymorphism analysis. Therefore, we conducted a case-control study to investigate the association of the CDH1 - 160C → A promoter polymorphism and haplotypes for cancer risk related to sporadic diffuse and intestinal gastric cancer by direct sequencing analysis. |
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