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Evaluation of a standardized treatment regimen of anti-tuberculosis drugs for patients with multi-drug-resistant tuberculosis (STREAM): study protocol for a randomized controlled trial

Overview of attention for article published in Trials, September 2014
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Title
Evaluation of a standardized treatment regimen of anti-tuberculosis drugs for patients with multi-drug-resistant tuberculosis (STREAM): study protocol for a randomized controlled trial
Published in
Trials, September 2014
DOI 10.1186/1745-6215-15-353
Pubmed ID
Authors

Andrew J Nunn, ID Rusen, Armand Van Deun, Gabriela Torrea, Patrick PJ Phillips, Chen-Yuan Chiang, S Bertel Squire, Jason Madan, Sarah K Meredith

Abstract

In contrast to drug-sensitive tuberculosis, the guidelines for the treatment of multi-drug-resistant tuberculosis (MDR-TB) have a very poor evidence base; current recommendations, based on expert opinion, are that patients should be treated for a minimum of 20 months. A series of cohort studies conducted in Bangladesh identified a nine-month regimen with very promising results. There is a need to evaluate this regimen in comparison with the currently recommended regimen in a randomized controlled trial in a variety of settings, including patients with HIV-coinfection.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 268 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Canada 1 <1%
Unknown 266 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 54 20%
Researcher 40 15%
Student > Bachelor 26 10%
Other 22 8%
Student > Ph. D. Student 21 8%
Other 46 17%
Unknown 59 22%
Readers by discipline Count As %
Medicine and Dentistry 105 39%
Pharmacology, Toxicology and Pharmaceutical Science 15 6%
Agricultural and Biological Sciences 14 5%
Social Sciences 13 5%
Biochemistry, Genetics and Molecular Biology 12 4%
Other 42 16%
Unknown 67 25%