Title |
Evaluation of a standardized treatment regimen of anti-tuberculosis drugs for patients with multi-drug-resistant tuberculosis (STREAM): study protocol for a randomized controlled trial
|
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Published in |
Trials, September 2014
|
DOI | 10.1186/1745-6215-15-353 |
Pubmed ID | |
Authors |
Andrew J Nunn, ID Rusen, Armand Van Deun, Gabriela Torrea, Patrick PJ Phillips, Chen-Yuan Chiang, S Bertel Squire, Jason Madan, Sarah K Meredith |
Abstract |
In contrast to drug-sensitive tuberculosis, the guidelines for the treatment of multi-drug-resistant tuberculosis (MDR-TB) have a very poor evidence base; current recommendations, based on expert opinion, are that patients should be treated for a minimum of 20 months. A series of cohort studies conducted in Bangladesh identified a nine-month regimen with very promising results. There is a need to evaluate this regimen in comparison with the currently recommended regimen in a randomized controlled trial in a variety of settings, including patients with HIV-coinfection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 67% |
Switzerland | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
Unknown | 266 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 54 | 20% |
Researcher | 40 | 15% |
Student > Bachelor | 26 | 10% |
Other | 22 | 8% |
Student > Ph. D. Student | 21 | 8% |
Other | 46 | 17% |
Unknown | 59 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 105 | 39% |
Pharmacology, Toxicology and Pharmaceutical Science | 15 | 6% |
Agricultural and Biological Sciences | 14 | 5% |
Social Sciences | 13 | 5% |
Biochemistry, Genetics and Molecular Biology | 12 | 4% |
Other | 42 | 16% |
Unknown | 67 | 25% |