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Small volume plasma exchange for Guillain-Barré syndrome in resource poor settings: a safety and feasibility study

Overview of attention for article published in Pilot and Feasibility Studies, September 2017
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Title
Small volume plasma exchange for Guillain-Barré syndrome in resource poor settings: a safety and feasibility study
Published in
Pilot and Feasibility Studies, September 2017
DOI 10.1186/s40814-017-0185-0
Pubmed ID
Authors

Md. Badrul Islam, Zhahirul Islam, Shafiqur Rahman, Hubert P. Endtz, Margreet C. Vos, Mathieu van der Jagt, Pieter A. van Doorn, Bart C. Jacobs, Quazi D. Mohammad

Abstract

In Bangladesh, most patients with Guillain-Barré syndrome (GBS) cannot afford standard treatment with intravenous immunoglobulin (IVIG) or a standard plasma exchange (PE) course, which partly explains the high rate of mortality and residual disability associated with GBS in this country. Small volume plasma exchange (SVPE) is an affordable and potentially effective alternative form of plasma exchange. SVPE is the repeated removal of small volumes of supernatant plasma over several days via sedimentation of patient whole blood. The aim of this study is to define the clinical feasibility and safety of SVPE in patients with GBS in resource poor settings. A total of 20 adult patients with GBS will be enrolled for SVPE at a single center in Bangladesh. Six daily sessions of whole blood sedimentation and plasma removal will be performed in all patients with GBS with a target to remove an overall volume of at least 8 liters (L) of plasma over a total of 8 days. Serious adverse events (SAE) are defined as the number of patients developing severe sepsis associated with the central venous catheter or deep venous thrombosis in the limb where the catheter is placed for SVPE. Based upon a predictive success rate of 75%, the SVPE procedure will be considered safe if less than 5 of 20 SVPE-treated GBS patients have a SAE. The procedure will be considered feasible if 8 L of plasma can be removed in at least 15 of 20 patients with GBS who receive SVPE. In addition, detailed clinical and neurological outcome assessments will be performed until discharge of the patient from the hospital and up to 4 weeks after study entry. This is the first clinical study to evaluate the feasibility and safety of SVPE as a potential alternative low-cost treatment for the patients with GBS in resource poor settings. Clinicaltrials.gov NCT02780570.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 244 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 244 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 4 2%
Researcher 3 1%
Student > Master 3 1%
Student > Bachelor 3 1%
Other 2 <1%
Other 7 3%
Unknown 222 91%
Readers by discipline Count As %
Medicine and Dentistry 12 5%
Pharmacology, Toxicology and Pharmaceutical Science 2 <1%
Neuroscience 2 <1%
Immunology and Microbiology 2 <1%
Computer Science 1 <1%
Other 3 1%
Unknown 222 91%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2017.
All research outputs
#19,064,965
of 23,622,736 outputs
Outputs from Pilot and Feasibility Studies
#879
of 1,089 outputs
Outputs of similar age
#247,679
of 321,966 outputs
Outputs of similar age from Pilot and Feasibility Studies
#13
of 16 outputs
Altmetric has tracked 23,622,736 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,089 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,966 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.