↓ Skip to main content

Therapeutic drug monitoring: linezolid too?

Overview of attention for article published in Critical Care, September 2014
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
6 tweeters

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
44 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Therapeutic drug monitoring: linezolid too?
Published in
Critical Care, September 2014
DOI 10.1186/s13054-014-0525-x
Pubmed ID
Authors

Guy A Richards, Adrian J Brink

Abstract

Numerous factors interfere with the ability to achieve optimal pharmacokinetic and pharmacodynamic targets and this has been associated with greater mortality and lower cure rates. The recent study by Zoller and colleagues examining linezolid levels in critically ill patients emphasises this point. Their study is unique in the description of the intra-patient and inter-patient variability that occurs and in the degree to which therapy is inadequate; 63% of patients had insufficient levels and only 17% maintained optimal trough values (between 2 and 10 mg/l) throughout the 4 study days. Precisely why this result occurred is uncertain because albumin levels, free linezolid pharmacokinetics and the presence of augmented renal clearance were not recorded in the current study. The extent of this variability makes the case for therapeutic drug monitoring since an area under the inhibitory curve greater than 80 to 120 and the time above the minimum inhibitory concentration over the entire dosing interval strongly correlate with linezolid treatment efficacy. Accordingly, therapeutic drug monitoring where available or, if not available, alternative approaches to drug delivery such as continuous infusion or a dose increase - but particularly the former - may be the answer.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Other 10 23%
Researcher 8 18%
Student > Bachelor 6 14%
Student > Ph. D. Student 5 11%
Student > Master 4 9%
Other 6 14%
Unknown 5 11%
Readers by discipline Count As %
Medicine and Dentistry 22 50%
Pharmacology, Toxicology and Pharmaceutical Science 9 20%
Chemistry 3 7%
Arts and Humanities 2 5%
Agricultural and Biological Sciences 1 2%
Other 1 2%
Unknown 6 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2019.
All research outputs
#8,150,290
of 15,467,979 outputs
Outputs from Critical Care
#3,305
of 4,897 outputs
Outputs of similar age
#78,017
of 205,066 outputs
Outputs of similar age from Critical Care
#80
of 131 outputs
Altmetric has tracked 15,467,979 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,897 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,066 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 131 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.