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Therapeutic drug monitoring: linezolid too?

Overview of attention for article published in Critical Care, September 2014
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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6 X users

Citations

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26 Dimensions

Readers on

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54 Mendeley
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Title
Therapeutic drug monitoring: linezolid too?
Published in
Critical Care, September 2014
DOI 10.1186/s13054-014-0525-x
Pubmed ID
Authors

Guy A Richards, Adrian J Brink

Abstract

Numerous factors interfere with the ability to achieve optimal pharmacokinetic and pharmacodynamic targets and this has been associated with greater mortality and lower cure rates. The recent study by Zoller and colleagues examining linezolid levels in critically ill patients emphasises this point. Their study is unique in the description of the intra-patient and inter-patient variability that occurs and in the degree to which therapy is inadequate; 63% of patients had insufficient levels and only 17% maintained optimal trough values (between 2 and 10 mg/l) throughout the 4 study days. Precisely why this result occurred is uncertain because albumin levels, free linezolid pharmacokinetics and the presence of augmented renal clearance were not recorded in the current study. The extent of this variability makes the case for therapeutic drug monitoring since an area under the inhibitory curve greater than 80 to 120 and the time above the minimum inhibitory concentration over the entire dosing interval strongly correlate with linezolid treatment efficacy. Accordingly, therapeutic drug monitoring where available or, if not available, alternative approaches to drug delivery such as continuous infusion or a dose increase - but particularly the former - may be the answer.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Other 9 17%
Researcher 9 17%
Student > Bachelor 6 11%
Student > Ph. D. Student 6 11%
Student > Master 5 9%
Other 6 11%
Unknown 13 24%
Readers by discipline Count As %
Medicine and Dentistry 23 43%
Pharmacology, Toxicology and Pharmaceutical Science 11 20%
Chemistry 3 6%
Arts and Humanities 2 4%
Agricultural and Biological Sciences 1 2%
Other 1 2%
Unknown 13 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2019.
All research outputs
#14,599,900
of 25,373,627 outputs
Outputs from Critical Care
#4,804
of 6,554 outputs
Outputs of similar age
#123,359
of 258,690 outputs
Outputs of similar age from Critical Care
#72
of 115 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,690 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 115 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.