Title |
Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition
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Published in |
Molecular Neurodegeneration, September 2014
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DOI | 10.1186/1750-1326-9-36 |
Pubmed ID | |
Authors |
Silvia S Kang, Patricio R Jeraldo, Aishe Kurti, Margret E Berg Miller, Marc D Cook, Keith Whitlock, Nigel Goldenfeld, Jeffrey A Woods, Bryan A White, Nicholas Chia, John D Fryer |
Abstract |
The ingestion of a high-fat diet (HFD) and the resulting obese state can exert a multitude of stressors on the individual including anxiety and cognitive dysfunction. Though many studies have shown that exercise can alleviate the negative consequences of a HFD using metabolic readouts such as insulin and glucose, a paucity of well-controlled rodent studies have been published on HFD and exercise interactions with regard to behavioral outcomes. This is a critical issue since some individuals assume that HFD-induced behavioral problems such as anxiety and cognitive dysfunction can simply be exercised away. To investigate this, we analyzed mice fed a normal diet (ND), ND with exercise, HFD diet, or HFD with exercise. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 16% |
Canada | 2 | 8% |
United Kingdom | 1 | 4% |
Comoros | 1 | 4% |
Virgin Islands, U.S. | 1 | 4% |
Unknown | 16 | 64% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 16 | 64% |
Scientists | 6 | 24% |
Practitioners (doctors, other healthcare professionals) | 2 | 8% |
Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 7 | 1% |
Ireland | 1 | <1% |
Italy | 1 | <1% |
Argentina | 1 | <1% |
Brazil | 1 | <1% |
Spain | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 464 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 84 | 18% |
Student > Bachelor | 80 | 17% |
Researcher | 61 | 13% |
Student > Master | 54 | 11% |
Student > Doctoral Student | 33 | 7% |
Other | 68 | 14% |
Unknown | 97 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 88 | 18% |
Medicine and Dentistry | 71 | 15% |
Biochemistry, Genetics and Molecular Biology | 50 | 10% |
Neuroscience | 35 | 7% |
Psychology | 29 | 6% |
Other | 92 | 19% |
Unknown | 112 | 23% |