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Factors that may impact on immunosenescence: an appraisal

Overview of attention for article published in Immunity & Ageing, June 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

blogs
2 blogs

Citations

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106 Dimensions

Readers on

mendeley
149 Mendeley
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1 CiteULike
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Title
Factors that may impact on immunosenescence: an appraisal
Published in
Immunity & Ageing, June 2010
DOI 10.1186/1742-4933-7-7
Pubmed ID
Authors

Joseph Ongrádi, Valéria Kövesdi

Abstract

The increasing ratio of ageing population poses new challenges to healthcare systems. The elderly frequently suffer from severe infections. Vaccination could protect them against several infectious diseases, but it can be effective only if cells that are capable of responding are still present in the repertoire. Recent vaccination strategies in the elderly might achieve low effectiveness due to age-related immune impairment. Immunosenescence affects both the innate and adaptive immunity.Beside individual variations of genetic predisposition, epigenetic changes over the full course of human life exert immunomodulating effects. Disturbances in macrophage-derived cytokine release and reduction of the natural killer cell mediated cytotoxicity lead to increased frequency of infections. Ageing dampens the ability of B cells to produce antibodies against novel antigens. Exhausted memory B lymphocyte subsets replace naïve cells. Decline of cell-mediated immunity is the consequence of multiple changes, including thymic atrophy, reduced output of new T lymphocytes, accumulation of anergic memory cells, and deficiencies in cytokines production. Persistent viral and parasitic infections contribute to the loss of immunosurveillance and premature exhaustion of T cells. Reduced telomerase activity and Toll-like receptor expression can be improved by chemotherapy. Reversion of thymic atrophy could be achieved by thymus transplantation, depletion of accumulated dysfunctional naive T cells and herpesvirus-specific exhausted memory cells. Administration of interleukin (IL)-2, IL-7, IL-10, keratinocyte growth factor, thymic stromal lymphopoietin, as well as leptin and growth hormone boost thymopoiesis. In animals, several strategies have been explored to produce superior vaccines. Among them, virosomal vaccines containing polypeptide antigens or DNA plasmids as well as new adjuvanted vaccine formulations elicit higher dendritic cell activity and more effective serologic than conventional vaccines responses in the elderly. Hopefully, at least some of these approaches can be translated to human medicine in a not too far future.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Portugal 2 1%
Germany 1 <1%
United Kingdom 1 <1%
Chile 1 <1%
Japan 1 <1%
Spain 1 <1%
Unknown 139 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 23 15%
Student > Bachelor 23 15%
Student > Ph. D. Student 17 11%
Researcher 16 11%
Student > Doctoral Student 9 6%
Other 35 23%
Unknown 26 17%
Readers by discipline Count As %
Medicine and Dentistry 45 30%
Agricultural and Biological Sciences 29 19%
Biochemistry, Genetics and Molecular Biology 9 6%
Immunology and Microbiology 9 6%
Nursing and Health Professions 7 5%
Other 20 13%
Unknown 30 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2011.
All research outputs
#2,085,727
of 22,651,245 outputs
Outputs from Immunity & Ageing
#59
of 366 outputs
Outputs of similar age
#7,641
of 95,641 outputs
Outputs of similar age from Immunity & Ageing
#1
of 1 outputs
Altmetric has tracked 22,651,245 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 366 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.9. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,641 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them