Title |
A novel role for ezrin in breast cancer angio/lymphangiogenesis
|
---|---|
Published in |
Breast Cancer Research, September 2014
|
DOI | 10.1186/s13058-014-0438-2 |
Pubmed ID | |
Authors |
Abdi Ghaffari, Victoria Hoskin, Alvin Szeto, Maaike Hum, Navid Liaghati, Kanji Nakatsu, Yolanda Madarnas, Sandip Sengupta, Bruce E Elliott |
Abstract |
Recent evidence suggests that tumour lymphangiogenesis promotes lymph node metastasis, a major prognostic factor for survival of breast cancer patients. However, signaling mechanisms involved in tumour-induced lymphangiogenesis remain poorly understood. The expression of ezrin, a membrane cytoskeletal crosslinker and Src substrate, correlates with poor outcome in a diversity of cancers including breast. Furthermore, ezrin is essential in experimental invasion and metastasis models of breast cancer. Ezrin acts cooperatively with Src in the regulation of the Src-induced malignant phenotype and metastasis. However, it remains unclear if ezrin plays a role in Src-induced tumour angio/lymphangiogenesis. |
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Country | Count | As % |
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Brazil | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 18% |
Student > Doctoral Student | 5 | 13% |
Student > Ph. D. Student | 5 | 13% |
Student > Bachelor | 4 | 11% |
Student > Master | 4 | 11% |
Other | 8 | 21% |
Unknown | 5 | 13% |
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Medicine and Dentistry | 8 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Sports and Recreations | 1 | 3% |
Other | 1 | 3% |
Unknown | 6 | 16% |