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Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages

Overview of attention for article published in Cell & Bioscience, August 2014
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Title
Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages
Published in
Cell & Bioscience, August 2014
DOI 10.1186/2045-3701-4-39
Pubmed ID
Authors

Constance Lay Lay Saw, Anne Yuqing Yang, Mou-Tuan Huang, Yue Liu, Jong Hun Lee, Tin Oo Khor, Zheng-Yuan Su, Limin Shu, Yaoping Lu, Allan H Conney, Ah-Ng Tony Kong

Abstract

Nrf2 plays a critical role in defending against oxidative stress and inflammation. We previously reported that Nrf2 confers protection against ultraviolet-B (UVB)-induced inflammation, sunburn reaction, and is involved in sulforaphane-mediated photo-protective effects in the skin. In this study, we aimed to demonstrate the protective role of Nrf2 against inflammation-mediated extracellular matrix (ECM) damage induced by UVB irradiation. Ear biopsy weights were significantly increased in both Nrf2 wild-type (Nrf2 WT) and knockout (Nrf2 KO) mice one week after UVB irradiation. However, these weights increased more significantly in KO mice compared to WT mice, suggesting a greater inflammatory response in KO mice. In addition, we analyzed the protein expression of numerous markers, including macrophage inflammatory protein-2 (MIP-2), pro-matrix metalloproteinase-9 (MMP-9), and p53. p53, a regulator of DNA repair, was overexpressed in Nrf2 KO mice, indicating that the absence of Nrf2 led to more sustained DNA damage. There was also more substantial ECM degradation and increased inflammation in UVB-irradiated Nrf2 KO mice compared to UVB-irradiated WT mice. Furthermore, the protective effects of Nrf2 in response to UVB irradiation were mediated by increased HO-1 protein expression. Collectively, our results show that Nrf2 plays a key role in protecting against UVB irradiation and that the photo-protective effect of Nrf2 is closely related to the inhibition of ECM degradation and inflammation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 2%
Unknown 61 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 21%
Student > Ph. D. Student 9 15%
Student > Doctoral Student 7 11%
Student > Bachelor 7 11%
Student > Master 5 8%
Other 8 13%
Unknown 13 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 21%
Medicine and Dentistry 11 18%
Agricultural and Biological Sciences 8 13%
Neuroscience 3 5%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 7 11%
Unknown 17 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2014.
All research outputs
#6,942,562
of 22,764,165 outputs
Outputs from Cell & Bioscience
#154
of 922 outputs
Outputs of similar age
#66,559
of 230,127 outputs
Outputs of similar age from Cell & Bioscience
#2
of 8 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 922 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,127 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.