Title |
Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice
|
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Published in |
Journal of Biomedical Science, August 2010
|
DOI | 10.1186/1423-0127-17-s1-s20 |
Pubmed ID | |
Authors |
Takashi Ito, Shohei Oishi, Mika Takai, Yasushi Kimura, Yoriko Uozumi, Yasushi Fujio, Stephen W Schaffer, Junichi Azuma |
Abstract |
Taurine, a sulfur-containing beta-amino acid, is highly contained in heart and skeletal muscle. Taurine has a variety of biological actions, such as ion movement, calcium handling and cytoprotection in the cardiac and skeletal muscles. Meanwhile, taurine deficiency leads various pathologies, including dilated cardiomyopathy, in cat and fox. However, the essential role of taurine depletion on pathogenesis has not been fully clarified. To address the physiological role of taurine in mammalian tissues, taurine transporter-(TauT-) knockout models were recently generated. TauTKO mice exhibited loss of body weight, abnormal cardiac function and the reduced exercise capacity with tissue taurine depletion. In this chapter, we summarize pathological profile and histological feature of heart and skeletal muscle in TauTKO mice. |
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Geographical breakdown
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Demographic breakdown
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Researcher | 8 | 12% |
Professor > Associate Professor | 5 | 7% |
Other | 13 | 19% |
Unknown | 11 | 16% |
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