Title |
Evaluation of microarray-based DNA methylation measurement using technical replicates: the Atherosclerosis Risk In Communities (ARIC) Study
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Published in |
BMC Bioinformatics, September 2014
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DOI | 10.1186/1471-2105-15-312 |
Pubmed ID | |
Authors |
Maitreyee Bose, Chong Wu, James S Pankow, Ellen W Demerath, Jan Bressler, Myriam Fornage, Megan L Grove, Thomas H Mosley, Chindo Hicks, Kari North, Wen Hong Kao, Yu Zhang, Eric Boerwinkle, Weihua Guan |
Abstract |
DNA methylation is a widely studied epigenetic phenomenon; alterations in methylation patterns influence human phenotypes and risk of disease. As part of the Atherosclerosis Risk in Communities (ARIC) study, the Illumina Infinium HumanMethylation450 (HM450) BeadChip was used to measure DNA methylation in peripheral blood obtained from ~3000 African American study participants. Over 480,000 cytosine-guanine (CpG) dinucleotide sites were surveyed on the HM450 BeadChip. To evaluate the impact of technical variation, 265 technical replicates from 130 participants were included in the study. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 30% |
Spain | 1 | 10% |
United Kingdom | 1 | 10% |
France | 1 | 10% |
Unknown | 4 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 70% |
Scientists | 2 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 2% |
United States | 1 | 2% |
Unknown | 45 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 23% |
Researcher | 11 | 23% |
Student > Master | 5 | 11% |
Student > Bachelor | 3 | 6% |
Professor > Associate Professor | 3 | 6% |
Other | 7 | 15% |
Unknown | 7 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 23% |
Agricultural and Biological Sciences | 8 | 17% |
Medicine and Dentistry | 7 | 15% |
Computer Science | 5 | 11% |
Nursing and Health Professions | 2 | 4% |
Other | 3 | 6% |
Unknown | 11 | 23% |