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Treatment of human hepatocellular carcinoma by the oncolytic herpes simplex virus G47delta

Overview of attention for article published in Cancer Cell International, September 2014
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Title
Treatment of human hepatocellular carcinoma by the oncolytic herpes simplex virus G47delta
Published in
Cancer Cell International, September 2014
DOI 10.1186/s12935-014-0083-y
Pubmed ID
Authors

Jiani Wang, Lihua Xu, Weigen Zeng, Pan Hu, Musheng Zeng, Samuel D Rabkin, Renbin Liu

Abstract

Oncolytic herpes simplex virus (HSV) can replicate in and kill cancer cells while sparing the adjacent normal tissue. Hepatocellular carcinoma (HCC) is amongst the most common and lethal cancers, especially in Third World countries. In this study, the cytotoxicity of a third-generation oncolytic HSV, G47Δ, was investigated in different human HCC cell lines and in an immortalized human hepatic cell line. Additionally, subcutaneous models of HCC were established to evaluate the in vivo anti-tumor efficacy of G47Δ.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 4%
Unknown 26 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 22%
Student > Ph. D. Student 4 15%
Student > Master 4 15%
Student > Bachelor 3 11%
Professor 1 4%
Other 2 7%
Unknown 7 26%
Readers by discipline Count As %
Medicine and Dentistry 7 26%
Biochemistry, Genetics and Molecular Biology 5 19%
Agricultural and Biological Sciences 3 11%
Immunology and Microbiology 1 4%
Neuroscience 1 4%
Other 1 4%
Unknown 9 33%