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Attention Score in Context
| Title |
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease
|
|---|---|
| Published in |
Respiratory Research, September 2014
|
| DOI | 10.1186/s12931-014-0113-2 |
| Pubmed ID | |
| Authors |
Jin Hwa Lee, Michael H Cho, Craig P Hersh, Merry-Lynn N McDonald, James D Crapo, Per S Bakke, Amund Gulsvik, Alejandro P Comellas, Christine H Wendt, David A Lomas, Victor Kim, Edwin K Silverman |
| Abstract |
BackgroundChronic bronchitis (CB) is one of the classic phenotypes of COPD. The aims of our study were to investigate genetic variants associated with COPD subjects with CB relative to smokers with normal spirometry, and to assess for genetic differences between subjects with CB and without CB within the COPD population.MethodsWe analyzed data from current and former smokers from three cohorts: the COPDGene Study; GenKOLS (Bergen, Norway); and the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE). CB was defined as having a cough productive of phlegm on most days for at least 3 consecutive months per year for at least 2 consecutive years. CB COPD cases were defined as having both CB and at least moderate COPD based on spirometry. Our primary analysis used smokers with normal spirometry as controls; secondary analysis was performed using COPD subjects without CB as controls. Genotyping was performed on Illumina platforms; results were summarized using fixed-effect meta-analysis.ResultsFor CB COPD relative to smoking controls, we identified a new genome-wide significant locus on chromosome 11p15.5 (rs34391416, OR¿=¿1.93, P¿=¿4.99¿×¿10-8) as well as significant associations of known COPD SNPs within FAM13A. In addition, a GWAS of CB relative to those without CB within COPD subjects showed suggestive evidence for association on 1q23.3 (rs114931935, OR¿=¿1.88, P¿=¿4.99¿×¿10-7).ConclusionsWe found genome-wide significant associations with CB COPD on 4q22.1 (FAM13A) and 11p15.5 (EFCAB4A, CHID1 and AP2A2), and a locus associated with CB within COPD subjects on 1q23.3 (RPL31P11 and ATF6). This study provides further evidence that genetic variants may contribute to phenotypic heterogeneity of COPD.Trial registrationClinicalTrials.gov NCT00608764, NCT00292552. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 67% |
| Netherlands | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| Portugal | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 95 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 14% |
| Professor | 13 | 13% |
| Student > Ph. D. Student | 9 | 9% |
| Student > Bachelor | 9 | 9% |
| Professor > Associate Professor | 9 | 9% |
| Other | 23 | 23% |
| Unknown | 22 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 33 | 33% |
| Biochemistry, Genetics and Molecular Biology | 14 | 14% |
| Agricultural and Biological Sciences | 13 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Nursing and Health Professions | 2 | 2% |
| Other | 10 | 10% |
| Unknown | 24 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2020.
All research outputs
#15,739,529
of 25,373,627 outputs
Outputs from Respiratory Research
#1,762
of 3,062 outputs
Outputs of similar age
#137,188
of 262,315 outputs
Outputs of similar age from Respiratory Research
#27
of 48 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,315 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.