Title |
Guibitang, a traditional herbal medicine, induces apoptotic death in A431 cells by regulating the activities of mitogen-activated protein kinases
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Published in |
BMC Complementary Medicine and Therapies, September 2014
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DOI | 10.1186/1472-6882-14-344 |
Pubmed ID | |
Authors |
Nam-Hui Yim, Aeyung Kim, Chun Liang, Won-Kyung Cho, Jin Yeul Ma |
Abstract |
Guibi-tang (GBT), a traditional herbal formula, mainly has been shown to possess immune regulation, antioxidant and protective effect of the gastric mucosa. Constituent herbs of GBT are frequently used to treat various diseases; however, their pharmacological effects, especially on cancer cells, differ from those of GBT. Furthermore, the molecular mechanisms behind effects of GBT remain unclear. In the present study, we explored the mechanism of chemopreventive/chemotherapeutic efficacy of GBT against human squamous cell carcinoma without cytotoxicity in normal cells and proved the efficacy of GBT through performing in vivo xenograft assay. |
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