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X Demographics
Mendeley readers
Attention Score in Context
| Title |
HIV-associated synaptic degeneration
|
|---|---|
| Published in |
Molecular Brain, August 2017
|
| DOI | 10.1186/s13041-017-0321-z |
| Pubmed ID | |
| Authors |
Wenjuan Ru, Shao-Jun Tang |
| Abstract |
Human immunodeficiency virus (HIV) infection induces neuronal injuries, with almost 50% of infected individuals developing HIV-associated neurocognitive disorders (HAND). Although highly activate antiretroviral therapy (HAART) has significantly reduced the incidence of severe dementia, the overall prevalence of HAND remains high. Synaptic degeneration is emerging as one of the most relevant neuropathologies associate with HAND. Previous studies have reported critical roles of viral proteins and inflammatory responses in this pathogenesis. Infected cells, including macrophages, microglia and astrocytes, may release viral proteins and other neurotoxins to stimulate neurons and cause excessive calcium influx, overproduction of free radicals and disruption of neurotransmitter hemostasis. The dysregulation of neural circuits likely leads to synaptic damage and loss. Identification of the specific mechanism of the synaptic degeneration may facilitate the development of effective therapeutic approaches to treat HAND. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 20% |
| Canada | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 76 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 14% |
| Student > Master | 10 | 13% |
| Student > Bachelor | 10 | 13% |
| Researcher | 7 | 9% |
| Student > Doctoral Student | 4 | 5% |
| Other | 9 | 12% |
| Unknown | 25 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 18% |
| Medicine and Dentistry | 7 | 9% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Immunology and Microbiology | 4 | 5% |
| Psychology | 4 | 5% |
| Other | 15 | 20% |
| Unknown | 27 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2023.
All research outputs
#7,947,810
of 23,923,403 outputs
Outputs from Molecular Brain
#380
of 1,159 outputs
Outputs of similar age
#121,836
of 318,784 outputs
Outputs of similar age from Molecular Brain
#7
of 19 outputs
Altmetric has tracked 23,923,403 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,159 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,784 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.