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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transcriptional regulation of Caenorhabditis elegansFOXO/DAF-16 modulates lifespan
|
|---|---|
| Published in |
Longevity & Healthspan, April 2014
|
| DOI | 10.1186/2046-2395-3-5 |
| Pubmed ID | |
| Authors |
Ankita Bansal, Eun-Soo Kwon, Darryl Conte, Haibo Liu, Michael J Gilchrist, Lesley T MacNeil, Heidi A Tissenbaum |
| Abstract |
Insulin/IGF-1 signaling plays a central role in longevity across phylogeny. In C. elegans, the forkhead box O (FOXO) transcription factor, DAF-16, is the primary target of insulin/IGF-1 signaling, and multiple isoforms of DAF-16 (a, b, and d/f) modulate lifespan, metabolism, dauer formation, and stress resistance. Thus far, across phylogeny modulation of mammalian FOXOs and DAF-16 have focused on post-translational regulation with little focus on transcriptional regulation. In C. elegans, we have previously shown that DAF-16d/f cooperates with DAF-16a to promote longevity. In this study, we generated transgenic strains expressing near-endogenous levels of either daf-16a or daf-16d/f, and examined temporal expression of the isoforms to further define how these isoforms contribute to lifespan regulation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Unknown | 106 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 24% |
| Researcher | 20 | 19% |
| Student > Bachelor | 19 | 18% |
| Student > Master | 17 | 16% |
| Student > Doctoral Student | 4 | 4% |
| Other | 10 | 9% |
| Unknown | 12 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 41% |
| Biochemistry, Genetics and Molecular Biology | 35 | 32% |
| Neuroscience | 5 | 5% |
| Medicine and Dentistry | 5 | 5% |
| Engineering | 2 | 2% |
| Other | 4 | 4% |
| Unknown | 13 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2015.
All research outputs
#14,201,088
of 22,764,165 outputs
Outputs from Longevity & Healthspan
#23
of 26 outputs
Outputs of similar age
#120,351
of 227,107 outputs
Outputs of similar age from Longevity & Healthspan
#4
of 4 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 26 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.3. This one scored the same or higher as 3 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,107 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.