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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Gene suppression approaches to neurodegeneration
|
|---|---|
| Published in |
Alzheimer's Research & Therapy, October 2017
|
| DOI | 10.1186/s13195-017-0307-1 |
| Pubmed ID | |
| Authors |
Rhia Ghosh, Sarah J. Tabrizi |
| Abstract |
Gene suppression approaches have emerged over the last 20 years as a novel therapeutic approach for the treatment of neurodegenerative diseases. These include RNA interference and anti-sense oligonucleotides, both of which act at the post-transcriptional level, and genome-editing techniques, which aim to repair the responsible mutant gene. All serve to inhibit the expression of disease-causing proteins, leading to the potential prevention or even reversal of the disease phenotype. In this review we summarise the main developments in gene suppression strategies, using examples from Huntington's disease and other inherited causes of neurodegeneration, and explore how these might illuminate a path to tackle other proteinopathy-associated dementias in the future. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 100 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 17% |
| Student > Ph. D. Student | 16 | 16% |
| Student > Master | 13 | 13% |
| Researcher | 9 | 9% |
| Other | 6 | 6% |
| Other | 12 | 12% |
| Unknown | 27 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 21 | 21% |
| Medicine and Dentistry | 11 | 11% |
| Neuroscience | 10 | 10% |
| Agricultural and Biological Sciences | 8 | 8% |
| Psychology | 5 | 5% |
| Other | 18 | 18% |
| Unknown | 27 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2021.
All research outputs
#2,252,570
of 23,005,189 outputs
Outputs from Alzheimer's Research & Therapy
#501
of 1,241 outputs
Outputs of similar age
#46,154
of 322,951 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#6
of 21 outputs
Altmetric has tracked 23,005,189 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,241 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.0. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,951 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.