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Gene suppression approaches to neurodegeneration

Overview of attention for article published in Alzheimer's Research & Therapy, October 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)

Mentioned by

blogs
1 blog
twitter
5 tweeters
patent
1 patent
facebook
1 Facebook page

Citations

dimensions_citation
31 Dimensions

Readers on

mendeley
91 Mendeley
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Title
Gene suppression approaches to neurodegeneration
Published in
Alzheimer's Research & Therapy, October 2017
DOI 10.1186/s13195-017-0307-1
Pubmed ID
Authors

Rhia Ghosh, Sarah J. Tabrizi

Abstract

Gene suppression approaches have emerged over the last 20 years as a novel therapeutic approach for the treatment of neurodegenerative diseases. These include RNA interference and anti-sense oligonucleotides, both of which act at the post-transcriptional level, and genome-editing techniques, which aim to repair the responsible mutant gene. All serve to inhibit the expression of disease-causing proteins, leading to the potential prevention or even reversal of the disease phenotype. In this review we summarise the main developments in gene suppression strategies, using examples from Huntington's disease and other inherited causes of neurodegeneration, and explore how these might illuminate a path to tackle other proteinopathy-associated dementias in the future.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 91 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 18%
Student > Ph. D. Student 14 15%
Student > Master 13 14%
Researcher 7 8%
Other 6 7%
Other 16 18%
Unknown 19 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 22%
Medicine and Dentistry 10 11%
Neuroscience 9 10%
Agricultural and Biological Sciences 8 9%
Unspecified 6 7%
Other 19 21%
Unknown 19 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2021.
All research outputs
#2,142,210
of 21,244,293 outputs
Outputs from Alzheimer's Research & Therapy
#468
of 1,093 outputs
Outputs of similar age
#43,478
of 297,482 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#1
of 1 outputs
Altmetric has tracked 21,244,293 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,093 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.1. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,482 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them