Title |
Human paternal and maternal demographic histories: insights from high-resolution Y chromosome and mtDNA sequences
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Published in |
Investigative Genetics, September 2014
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DOI | 10.1186/2041-2223-5-13 |
Pubmed ID | |
Authors |
Sebastian Lippold, Hongyang Xu, Albert Ko, Mingkun Li, Gabriel Renaud, Anne Butthof, Roland Schröder, Mark Stoneking |
Abstract |
Comparisons of maternally-inherited mitochondrial DNA (mtDNA) and paternally-inherited non-recombining Y chromosome (NRY) variation have provided important insights into the impact of sex-biased processes (such as migration, residence pattern, and so on) on human genetic variation. However, such comparisons have been limited by the different molecular methods typically used to assay mtDNA and NRY variation (for example, sequencing hypervariable segments of the control region for mtDNA vs. genotyping SNPs and/or STR loci for the NRY). Here, we report a simple capture array method to enrich Illumina sequencing libraries for approximately 500 kb of NRY sequence, which we use to generate NRY sequences from 623 males from 51 populations in the CEPH Human Genome Diversity Panel (HGDP). We also obtained complete mtDNA genome sequences from the same individuals, allowing us to compare maternal and paternal histories free of any ascertainment bias. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 13 | 12% |
United Kingdom | 7 | 6% |
Spain | 6 | 6% |
Australia | 4 | 4% |
Belgium | 3 | 3% |
Netherlands | 3 | 3% |
Germany | 3 | 3% |
Canada | 3 | 3% |
France | 3 | 3% |
Other | 12 | 11% |
Unknown | 52 | 48% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 86 | 79% |
Scientists | 16 | 15% |
Science communicators (journalists, bloggers, editors) | 3 | 3% |
Practitioners (doctors, other healthcare professionals) | 3 | 3% |
Unknown | 1 | <1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 2% |
United Kingdom | 2 | <1% |
Netherlands | 1 | <1% |
Germany | 1 | <1% |
Unknown | 208 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 52 | 24% |
Student > Bachelor | 34 | 16% |
Researcher | 28 | 13% |
Student > Master | 28 | 13% |
Student > Doctoral Student | 14 | 6% |
Other | 41 | 19% |
Unknown | 20 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 86 | 40% |
Biochemistry, Genetics and Molecular Biology | 63 | 29% |
Social Sciences | 13 | 6% |
Arts and Humanities | 6 | 3% |
Medicine and Dentistry | 4 | 2% |
Other | 17 | 8% |
Unknown | 28 | 13% |