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The diminishing returns of atovaquone-proguanil for elimination of Plasmodium falciparum malaria: modelling mass drug administration and treatment

Overview of attention for article published in Malaria Journal, September 2014
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2 X users

Citations

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35 Dimensions

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76 Mendeley
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Title
The diminishing returns of atovaquone-proguanil for elimination of Plasmodium falciparum malaria: modelling mass drug administration and treatment
Published in
Malaria Journal, September 2014
DOI 10.1186/1475-2875-13-380
Pubmed ID
Authors

Richard J Maude, Chea Nguon, Arjen M Dondorp, Lisa J White, Nicholas J White

Abstract

Artemisinin resistance is a major threat to current efforts to eliminate Plasmodium falciparum malaria which rely heavily on the continuing efficacy of artemisinin combination therapy (ACT). It has been suggested that ACT should not be used in mass drug administration (MDA) in areas where artemisinin-resistant P. falciparum is prevalent, and that atovaquone-proguanil (A-P) might be a preferable alternative. However, a single point mutation in the cytochrome b gene confers high level resistance to atovaquone, and such mutant parasites arise frequently during treatment making A-P a vulnerable tool for elimination.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Burkina Faso 1 1%
Netherlands 1 1%
Unknown 73 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 18%
Student > Master 13 17%
Student > Ph. D. Student 11 14%
Other 6 8%
Student > Bachelor 4 5%
Other 15 20%
Unknown 13 17%
Readers by discipline Count As %
Medicine and Dentistry 25 33%
Agricultural and Biological Sciences 12 16%
Biochemistry, Genetics and Molecular Biology 7 9%
Social Sciences 5 7%
Chemistry 3 4%
Other 8 11%
Unknown 16 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2014.
All research outputs
#15,392,095
of 24,400,706 outputs
Outputs from Malaria Journal
#4,179
of 5,827 outputs
Outputs of similar age
#135,411
of 257,057 outputs
Outputs of similar age from Malaria Journal
#56
of 102 outputs
Altmetric has tracked 24,400,706 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,827 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,057 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 102 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.