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X Demographics
Mendeley readers
Attention Score in Context
| Title |
T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus
|
|---|---|
| Published in |
Arthritis Research & Therapy, October 2017
|
| DOI | 10.1186/s13075-017-1438-2 |
| Pubmed ID | |
| Authors |
Ya Liu, Shiyu Zhou, Jie Qian, Yan Wang, Xiang Yu, Dai Dai, Min Dai, Lingling Wu, Zhuojun Liao, Zhixin Xue, Jiehua Wang, Goujun Hou, Jianyang Ma, John B. Harley, Yuanjia Tang, Nan Shen |
| Abstract |
A hallmark of systemic lupus erythematosus is high titers of circulating autoantibodies. Recently, a novel CD11c(+) B-cell subset has been identified that is critical for the development of autoimmunity. However, the role of CD11c(+) B cells in the development of lupus is unclear. Chronic graft-versus-host disease (cGVHD) is a lupus-like syndrome with high autoantibody production. The purpose of this study was to explore the role of CD11c(+) B cells in the pathogenesis of lupus in cGVHD mice. cGVHD was induced by an intraperitoneal injection of 5 × 10(7) Bm12 splenocytes into B6 mice. Flow cytometry was used to analyze mice splenocytes and human samples. Magnetic beads were used to isolate mice B cells. Gene expression was determined by real-time quantitative polymerase chain reaction (RT-qPCR). Enzyme-linked immunosorbent assay (ELISA) was used to detect antibodies in serum and supernatants. The percentage and absolute number of CD11c(+) B cells was increased in cGVHD-induced lupus, with elevated levels of antichromatin immunoglobulin (Ig)G and IgG2a in sera. CD11c(+) plasma cells from cGVHD mice produced large amounts of antichromatin IgG2a upon stimulation. Depletion of CD11c(+) B cells reduced antichromatin IgG and IgG2a production. T-bet was upregulated in CD11c(+) B cells. Knockout of T-bet in B cells alleviated cGVHD-induced lupus. Importantly, the percentage of T-bet(+)CD11c(+) B cells increased in lupus patients and positively correlated with serum antichromatin levels. T-bet(+)CD11c(+) B cells promoted high antichromatin IgG production in the lupus-like disease model cGVHD. In lupus patients, the percentage of T-bet(+)CD11c(+) B cells was elevated and positively correlated with antichromatin antibodies. The findings provide potential therapeutic insight into lupus disease treatment. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 25% |
| France | 1 | 25% |
| United Kingdom | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 59 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 17% |
| Researcher | 8 | 14% |
| Student > Doctoral Student | 4 | 7% |
| Student > Master | 4 | 7% |
| Student > Postgraduate | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 22 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 17 | 29% |
| Medicine and Dentistry | 8 | 14% |
| Biochemistry, Genetics and Molecular Biology | 5 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
| Agricultural and Biological Sciences | 2 | 3% |
| Other | 2 | 3% |
| Unknown | 21 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2017.
All research outputs
#14,605,790
of 25,382,440 outputs
Outputs from Arthritis Research & Therapy
#2,123
of 3,380 outputs
Outputs of similar age
#161,316
of 330,919 outputs
Outputs of similar age from Arthritis Research & Therapy
#29
of 48 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,919 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.