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Effect of antimicrobials administered via liquid feed on the occurrence of sulphonamide and trimethoprim resistant Enterobacteriaceae: case-control study

Overview of attention for article published in Porcine Health Management, October 2017
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Title
Effect of antimicrobials administered via liquid feed on the occurrence of sulphonamide and trimethoprim resistant Enterobacteriaceae: case-control study
Published in
Porcine Health Management, October 2017
DOI 10.1186/s40813-017-0067-0
Pubmed ID
Authors

Oliver Heller, Roger Stephan, Sophie Thanner, Michael Hässig, Giuseppe Bee, Andreas Gutzwiller, Xaver Sidler

Abstract

Drugs for the treatment of groups of pigs receiving liquid feed are frequently mixed into the feed and administered via the pipelines of the feeding installations. In-feed antimicrobials may select antimicrobial resistant strains among the bacteria which form the biofilm of these pipelines and are shed into the liquid feed. In order to evaluate the risk of selecting antimicrobial resistant bacteria in the biofilm of liquid feeding installations, the effect of the administration of antimicrobials via the pipelines on the occurrence of antimicrobial resistance in the feed was examined in a case-control study. A premix containing either sulphonamide plus trimethoprim or sulphonamide plus chlortetracycline plus tylosin or chlortetracycline was administered via the pipelines to each batch of bought-in fattening pigs in 7, 3 and 3 case farms respectively, whereas antimicrobials had not been administered via the liquid feeding installation for at least 2 years in the 14 control farms. Enterobacteriaceae and sulphonamide-trimethoprim resistant Enterobacteriaceae were counted in twelve and eight feed samples collected in each case and in each control farm respectively during one fattening period. The semiparametric Generalized Estimating Equations (GEE) method was used for the statistical data analysis. The ratio of sulphonamide and trimethoprim resistant to total Enterobacteriaceae was higher in the feed of the case farms compared to the control farms (P < 0.001) and did not decrease after treatment during the fattening period. The administration of antimicrobials via the liquid feeding installation selects antibiotic resistant bacteria in the biofilm lining the pipelines, which may contaminate the liquid feed for extended periods and transmit their resistance genes to the gastrointestinal flora of the pigs. Alternatives to the administration of antimicrobials via pipelines of liquid feeding installations for group treatment should be developed.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 15%
Student > Postgraduate 2 15%
Researcher 2 15%
Student > Ph. D. Student 1 8%
Other 1 8%
Other 2 15%
Unknown 3 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 31%
Veterinary Science and Veterinary Medicine 2 15%
Economics, Econometrics and Finance 1 8%
Medicine and Dentistry 1 8%
Unknown 5 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2017.
All research outputs
#18,573,839
of 23,005,189 outputs
Outputs from Porcine Health Management
#186
of 222 outputs
Outputs of similar age
#247,363
of 323,064 outputs
Outputs of similar age from Porcine Health Management
#6
of 6 outputs
Altmetric has tracked 23,005,189 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 222 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,064 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.